MolNFT v1 · #137217 · protein
Conformational landscape of the P28-bound human proteasome regulatory particle
5VHS · 26S proteasome regulatory subunit 7: “Conformational landscape of the P28-bound human proteasome regulatory particle”. Electron microscopy, 1 ligand (ZN), 20 pockets (best druggability 0.88). MolNFT v1 #137217 on GenesisL1: 3D…
- PDB
- 5VHS
- Type
- protein
- Length
- 6,033 residues
- Chains
- 18
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome regulatory subunit 7; 26S proteasome regulatory subunit 4; 26S proteasome…
- EC
- 3.4.19.-
- UniProt
- P35998, P62191, P62195, P43686, P62333, P17980, Q99460, O43242, O00232, O00231, Q15008, P51665, Q9UNM6, P55036, O00487, P48556, P60896, Q13200
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 18 distinct chains · 51% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit 7 | protein | 338 | 36% helix, 10% strand | P35998 |
| B | 26S proteasome regulatory subunit 4 | protein | 317 | 35% helix, 10% strand | P62191 |
| C | 26S proteasome regulatory subunit 8 | protein | 349 | 43% helix, 11% strand | P62195 |
| D | 26S proteasome regulatory subunit 6B | protein | 332 | 42% helix, 10% strand | P43686 |
| E | 26S proteasome regulatory subunit 10B | protein | 313 | 41% helix, 11% strand | P62333 |
| F | 26S proteasome regulatory subunit 6A | protein | 339 | 39% helix, 11% strand | P17980 |
| U | 26S proteasome non-ATPase regulatory subunit 1 | protein | 751 | 52% helix, 2% strand | Q99460 |
| V | 26S proteasome non-ATPase regulatory subunit 3 | protein | 262 | 56% helix, 1% strand | O43242 |
| W | 26S proteasome non-ATPase regulatory subunit 12 | protein | 391 | 59% helix, 1% strand | O00232 |
| X | 26S proteasome non-ATPase regulatory subunit 11 | protein | 280 | 70% helix, 0% strand | O00231 |
| Y | 26S proteasome non-ATPase regulatory subunit 6 | protein | 378 | 66% helix, 2% strand | Q15008 |
| Z | 26S proteasome non-ATPase regulatory subunit 7 | protein | 286 | 44% helix, 15% strand | P51665 |
| a | 26S proteasome non-ATPase regulatory subunit 13 | protein | 374 | 63% helix, 1% strand | Q9UNM6 |
| b | 26S proteasome non-ATPase regulatory subunit 4 | protein | 191 | 31% helix, 17% strand | P55036 |
| c | 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) | protein | 287 | 39% helix, 13% strand | O00487 |
| d | 26S proteasome non-ATPase regulatory subunit 8 | protein | 176 | 54% helix, 4% strand | P48556 |
| e | 26S proteasome complex subunit SEM1 | protein | 33 | 61% helix, 0% strand | P60896 |
| f | 26S proteasome non-ATPase regulatory subunit 2 | protein | 636 | 65% helix, 0% strand | Q13200 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains c
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1180 | 0.88 | 0.89 | 134 | empty |
| 2 | 1137 | 0.87 | 0.88 | 121 | empty |
| 3 | 617 | 0.87 | 0.91 | 71 | empty |
| 4 | 758 | 0.84 | 0.87 | 98 | empty |
| 5 | 1162 | 0.83 | 0.84 | 121 | empty |
Interfaces
56 interfaces between chains.
- Z–c · 3593 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 3040 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 2202 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 2137 Ų buried · 9 hydrogen bonds · protein-protein
- X–Y · 1782 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5VHS · Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle · the same entry in another collection · chain X against X, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35998
- Every structure of UniProt P62191
- Every structure of UniProt P62195
- Every structure of UniProt P43686
- Every structure of UniProt P62333
- Every structure of UniProt P17980
- Every structure of UniProt Q99460
- Every structure of UniProt O43242
- Every structure of UniProt O00232
- Every structure of UniProt O00231
- Every structure of UniProt Q15008
- Every structure of UniProt P51665
- Every structure of UniProt Q9UNM6
- Every structure of UniProt P55036
- Every structure of UniProt O00487
- Every structure of UniProt P48556
- Every structure of UniProt P60896
- Every structure of UniProt Q13200
- Elsewhere: RCSB PDB 5VHS · PDBe 5VHS · UniProt P35998 · UniProt P62191 · UniProt P62195 · UniProt P43686 · UniProt P62333 · UniProt P17980 · UniProt Q99460 · UniProt O43242 · UniProt O00232 · UniProt O00231 · UniProt Q15008 · UniProt P51665 · UniProt Q9UNM6 · UniProt P55036 · UniProt O00487 · UniProt P48556 · UniProt P60896 · UniProt Q13200
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