UniProt O00487
26S proteasome non-ATPase regulatory subunit 14 (O00487)
26S proteasome non-ATPase regulatory subunit 14 (UniProt O00487), EC 3.4.19.-: 27 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 35 pockets. Binding sites, druggability and experiment against…
- UniProt
- O00487
- Protein
- 26S proteasome non-ATPase regulatory subunit 14
- EC
- 3.4.19.-
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 35 · 9 records with a druggable one
Structures
28 records of O00487 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | V | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | V, 9 | — | — |
| 5L4K | The human 26S proteasome lid | electron microscopy | V | — | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | V | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | q | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | c | ZN | 5 (best 0.84) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | c | ZN | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | c | ZN | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | c | ZN | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | c | ZN | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | c | ZN | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | c | ZN | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | c | ZN | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | c | ZN | 7 (best 0.86) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | c | ZN | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | c | ZN | — |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | c | ZN | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | c | ZN | 4 (best 0.89) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | c | ZN | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | c | ZN | 5 (best 0.88) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | c | ZN | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | c | ZN | 3 (best 0.82) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | c | ZN | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | c | ZN | 2 (best 0.80) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | c | ZN | — |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | c | — | 3 (best 0.87) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | c | ZN | 3 (best 0.79) |
| O00487 | AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 14 (O00487) | predicted | A | — | 3 (best 0.51) |
Ligands
- ZN · Zinc ion · in 21 records
Experiment against prediction
- 5GJQ chain V against the predicted model O00487: TM-score 0.94, RMSD 1.55 Å
- 5GJR chain V against the predicted model O00487: TM-score 0.94, RMSD 1.56 Å
- 7W39 chain c against the predicted model O00487: TM-score 0.93, RMSD 1.73 Å
- 6MSD chain c against the predicted model O00487: TM-score 0.91, RMSD 2.09 Å
- 9E8Q chain c against the predicted model O00487: TM-score 0.91, RMSD 2.18 Å
- 8JRI chain c against the predicted model O00487: TM-score 0.90, RMSD 2.12 Å
- 5L4K chain V against the predicted model O00487: TM-score 0.89, RMSD 2.24 Å
- 5M32 chain q against the predicted model O00487: TM-score 0.88, RMSD 2.37 Å
- 5T0G chain c against the predicted model O00487: TM-score 0.87, RMSD 2.27 Å
- 5T0G chain c against the predicted model O00487: TM-score 0.87, RMSD 2.27 Å
Elsewhere
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