UniProt O00232
26S proteasome non-ATPase regulatory subunit 12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (UniProt O00232): 81 experimental structures and 1 predicted model on GenesisL1, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00232
- Protein
- 26S proteasome non-ATPase regulatory subunit 12
- Experimental structures
- 81
- Predicted models
- 1
- Pockets
- 67 · 41 records with a druggable one
Structures
82 records of O00232 in the MolNFT archive: 81 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | P | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | P, 3 | — | — |
| 5L4K | The human 26S proteasome lid | electron microscopy | P | — | 3 (best 0.71) |
| 5L4K | The human 26S proteasome lid | electron microscopy | P | — | — |
| 5LN3 | The human 26S Proteasome at 6.8 Ang. | electron microscopy | P | — | 1 (best 0.86) |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | P | — | — |
| 5M32 | Human 26S proteasome in complex with Oprozomib | electron microscopy | k | — | 2 (best 0.78) |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | k | — | — |
| 5T0C | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | AW, BW | — | 1 (best 0.81) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | 1 (best 0.82) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | 1 (best 0.82) |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | 1 (best 0.79) |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | W | — | — |
| 5VFP | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | W | — | 3 (best 0.83) |
| 5VFQ | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | W | — | 2 (best 0.81) |
| 5VFR | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | W | — | 1 (best 0.80) |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | W | — | — |
| 5VFS | Nucleotide-Driven Triple-State Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | W | — | 1 (best 0.85) |
| 5VFT | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | W | — | 1 (best 0.81) |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | W | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | W | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | W | — | 4 (best 0.86) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | W | — | — |
| 5VHF | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | W | — | 5 (best 0.87) |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | W | — | — |
| 5VHH | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | W | — | 3 (best 0.86) |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | W | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | W | — | 4 (best 0.89) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | W | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | W | — | 4 (best 0.88) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | W | — | — |
| 6MSB | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | 1 (best 0.80) |
| 6MSE | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | 1 (best 0.78) |
| 6MSG | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | 1 (best 0.78) |
| 6MSH | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | 1 (best 0.83) |
| 6MSJ | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | — |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | W | — | 1 (best 0.79) |
| 6WJD | SA-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | W | — | 1 (best 0.79) |
| 6WJN | SD-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | W | — | 2 (best 0.88) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | W | — | — |
| 7QXN | Proteasome-ZFAND5 Complex Z+A state | electron microscopy | W | — | 1 (best 0.78) |
| 7QXP | Proteasome-ZFAND5 Complex Z+B state | electron microscopy | W | — | 1 (best 0.78) |
| 7QXU | Proteasome-ZFAND5 Complex Z+C state | electron microscopy | W | — | — |
| 7QXW | Proteasome-ZFAND5 Complex Z+D state | electron microscopy | W | — | 2 (best 0.83) |
| 7QXX | Proteasome-ZFAND5 Complex Z+E state | electron microscopy | W | — | 1 (best 0.80) |
| 7QY7 | Proteasome-ZFAND5 Complex Z-A state | electron microscopy | W | — | — |
| 7QYA | Proteasome-ZFAND5 Complex Z-B state | electron microscopy | W | — | 2 (best 0.80) |
| 7QYB | Proteasome-ZFAND5 Complex Z-C state | electron microscopy | W | — | 1 (best 0.80) |
| 7W37 | Structure of USP14-bound human 26S proteasome in state EA1_UBL | electron microscopy | W | — | — |
| 7W38 | Structure of USP14-bound human 26S proteasome in state EA2.0_UBL | electron microscopy | W | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | W | — | — |
| 7W3A | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14 | electron microscopy | W | — | — |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | W | — | 1 (best 0.78) |
| 7W3C | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED0_USP14 | electron microscopy | W | — | — |
| 7W3F | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED1_USP14 | electron microscopy | W | — | — |
22 records more on the page itself.
Experiment against prediction
- 8USB chain W against the predicted model O00232: TM-score 0.98, RMSD 1.19 Å
- 9E8H chain W against the predicted model O00232: TM-score 0.98, RMSD 1.19 Å
- 9E8I chain W against the predicted model O00232: TM-score 0.98, RMSD 1.20 Å
- 5GJQ chain P against the predicted model O00232: TM-score 0.95, RMSD 1.81 Å
- 5GJR chain P against the predicted model O00232: TM-score 0.94, RMSD 1.83 Å
- 7W38 chain W against the predicted model O00232: TM-score 0.93, RMSD 2.03 Å
- 7W39 chain W against the predicted model O00232: TM-score 0.92, RMSD 2.09 Å
- 7W37 chain W against the predicted model O00232: TM-score 0.92, RMSD 2.10 Å
- 7QXX chain W against the predicted model O00232: TM-score 0.92, RMSD 1.91 Å
- 9E8O chain W against the predicted model O00232: TM-score 0.92, RMSD 2.39 Å
Elsewhere
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