UniProt Q99460
26S proteasome non-ATPase regulatory subunit 1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (UniProt Q99460): 40 experimental structures on GenesisL1, 43 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q99460
- Protein
- 26S proteasome non-ATPase regulatory subunit 1
- Experimental structures
- 40
- Predicted models
- 0
- Pockets
- 43 · 13 records with a druggable one
Structures
40 records of Q99460 in the MolNFT archive: 40 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | N | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | N, 1 | — | — |
| 5L4K | The human 26S proteasome lid | electron microscopy | N | — | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | N | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | i | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | U | — | 3 (best 0.84) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | U | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | U | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | U | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | U | — | — |
| 5V1Y | Crystal structure of the ternary RPN13 pru-RPN2 (940-953)-ubiquitin complex | x-ray diffraction | E, F | — | — |
| 5V1Z | Crystal structure of the RPN13 pru-RPN2 (932-953)-ubiquitin complex | x-ray diffraction | F, E | — | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | U | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | U | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | U | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | U | — | 6 (best 0.86) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | U | — | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | U | — | — |
| 5VHH | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | U | — | 5 (best 0.86) |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | U | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | U | — | 3 (best 0.87) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | U | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | U | — | 4 (best 0.87) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | U | — | — |
| 6CO4 | Structure of the RPN13-RPN2 complex provides insights for RPN13 and UCH37 as anticancer targets | solution nmr | B | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | U | — | 4 (best 0.84) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | U | — | 3 (best 0.82) |
| 6OI4 | RPN13 (19-132)-RPN2 (940-952) PY950-ub complex | x-ray diffraction | E, F | — | — |
| 6UYI | HRPN13:HRPN2:K48-diubiquitin | solution nmr | B | — | — |
| 6UYJ | hRpn13:hRpn2:K48-diubiquitin | solution nmr | B | — | — |
| 6UYJ | HRPN13:HRPN2:K48-diubiquitin | solution nmr | B | — | — |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | U | — | — |
| 7QY7 | Proteasome-ZFAND5 Complex Z-A state | electron microscopy | U | — | 3 (best 0.85) |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | U | — | 3 (best 0.86) |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | U | — | 2 (best 0.82) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | U | — | — |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | U | — | 2 (best 0.87) |
| 9E8L | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral staircase | electron microscopy | U | — | 4 (best 0.82) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | U | — | 1 (best 0.83) |
| Q99460 | AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 1 (Q99460) | — | — | — |
Elsewhere
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