UniProt P17980
26S proteasome regulatory subunit 6A (P17980)
26S proteasome regulatory subunit 6A (UniProt P17980): 50 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 91 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P17980
- Protein
- 26S proteasome regulatory subunit 6A
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 91 · 25 records with a druggable one
Structures
51 records of P17980 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | M | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | M, 0 | ADP | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | M | ATP, MG | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | M | — | — |
| 5M32 | Human 26S proteasome in complex with Oprozomib | electron microscopy | g | ADP | 3 (best 0.82) |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | g | ADP | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | F | ATP | 6 (best 0.88) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | F | ATP | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | F | ADP | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | F | ATP | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | F | ATP | 4 (best 0.83) |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | F | ATP | — |
| 5VFQ | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | F | AGS | 5 (best 0.84) |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | F | AGS | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | F | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | F | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 1 (best 0.83) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHH | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 2 (best 0.84) |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 2 (best 0.83) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHJ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHM | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHN | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHO | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 5 (best 0.83) |
| 5VHO | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHP | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHQ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 2 (best 0.88) |
| 5VHQ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHR | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 5 (best 0.83) |
| 5VHR | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | F | — | 4 (best 0.87) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | F | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | F | ATP, MG, ADP | 4 (best 0.84) |
| 6MSJ | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | F | ADP | 5 (best 0.86) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | F | ATP, MG | 4 (best 0.85) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | F | AGS | — |
| 7QXX | Proteasome-ZFAND5 Complex Z+E state | electron microscopy | F | ATP, MG, ADP | 3 (best 0.83) |
| 7QY7 | Proteasome-ZFAND5 Complex Z-A state | electron microscopy | F | — | 4 (best 0.88) |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | F | ATP, MG, ADP | 4 (best 0.85) |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | F | ATP, ADP | 3 (best 0.86) |
| 7W3H | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | electron microscopy | F | ATP, MG | 4 (best 0.81) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | F | ATP | — |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | F | ATP, ADP, MG | 6 (best 0.81) |
| 9E8I | Human proteasome in resting state conformation bound to TXNL1 in Forward conformation | electron microscopy | F | ATP, MG | 5 (best 0.82) |
| 9E8L | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral staircase | electron microscopy | F | ATP, MG | 4 (best 0.84) |
| 9E8N | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt3 at top of spiral staircase | electron microscopy | F | ATP, MG | 2 (best 0.83) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | F | ADP | 2 (best 0.82) |
| P17980 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 6A (P17980) | predicted | A | — | 2 (best 0.55) |
Ligands
Experiment against prediction
- 9E8L chain F against the predicted model P17980: TM-score 0.94, RMSD 1.85 Å
- 9E8I chain F against the predicted model P17980: TM-score 0.93, RMSD 2.02 Å
- 9E8N chain F against the predicted model P17980: TM-score 0.92, RMSD 2.25 Å
- 5GJR chain M against the predicted model P17980: TM-score 0.90, RMSD 2.45 Å
- 5M32 chain g against the predicted model P17980: TM-score 0.90, RMSD 2.33 Å
- 5M32 chain g against the predicted model P17980: TM-score 0.90, RMSD 2.33 Å
- 5GJQ chain M against the predicted model P17980: TM-score 0.90, RMSD 2.52 Å
- 5T0G chain F against the predicted model P17980: TM-score 0.90, RMSD 2.37 Å
- 5T0G chain F against the predicted model P17980: TM-score 0.90, RMSD 2.37 Å
- 5T0I chain F against the predicted model P17980: TM-score 0.89, RMSD 2.70 Å
Elsewhere
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