UniProt P35998
26S proteasome regulatory subunit 7 (P35998)
26S proteasome regulatory subunit 7 (UniProt P35998): 35 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35998
- Protein
- 26S proteasome regulatory subunit 7
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 35 · 9 records with a druggable one
Structures
36 records of P35998 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | H | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | H, v | ADP | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | H | ATP, MG | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | H | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | c | ADP | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | A | ATP | 5 (best 0.88) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | A | ATP | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | A | ADP | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | A | ATP | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | A | ATP | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | A | AGS | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | A | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | A | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | A | — | 1 (best 0.83) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | A | — | — |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHJ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHM | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHN | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHO | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHP | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHQ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | A | — | 5 (best 0.88) |
| 5VHQ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHR | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | A | — | 3 (best 0.78) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | A | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | A | ATP, MG, ADP | 6 (best 0.84) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | A | AGS | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | A | ATP, MG, ADP | 5 (best 0.85) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | A | ATP | — |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | A | ATP, MG, ADP | 5 (best 0.81) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | A | ADP | 4 (best 0.81) |
| P35998 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 7 (P35998) | predicted | A | — | 1 (best 0.52) |
Ligands
Experiment against prediction
- 5M32 chain c against the predicted model P35998: TM-score 0.96, RMSD 1.43 Å
- 5T0G chain A against the predicted model P35998: TM-score 0.92, RMSD 2.17 Å
- 5T0G chain A against the predicted model P35998: TM-score 0.92, RMSD 2.17 Å
- 5VFT chain A against the predicted model P35998: TM-score 0.92, RMSD 2.20 Å
- 5T0H chain A against the predicted model P35998: TM-score 0.92, RMSD 2.20 Å
- 5T0I chain A against the predicted model P35998: TM-score 0.90, RMSD 2.46 Å
- 5VFU chain A against the predicted model P35998: TM-score 0.90, RMSD 2.46 Å
- 5GJR chain H against the predicted model P35998: TM-score 0.90, RMSD 1.61 Å
- 5GJQ chain H against the predicted model P35998: TM-score 0.89, RMSD 2.13 Å
- 5L4G chain H against the predicted model P35998: TM-score 0.89, RMSD 2.15 Å
Elsewhere
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