UniProt P48556
26S proteasome non-ATPase regulatory subunit 8 (P48556)
26S proteasome non-ATPase regulatory subunit 8 (UniProt P48556): 32 experimental structures and 1 predicted model on GenesisL1, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P48556
- Protein
- 26S proteasome non-ATPase regulatory subunit 8
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 30 · 12 records with a druggable one
Structures
33 records of P48556 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | T | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | T, 7 | — | — |
| 5L4K | The human 26S proteasome lid | electron microscopy | T | — | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | T | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | r | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | d | — | 2 (best 0.82) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | d | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | d | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | d | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | d | — | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | d | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | d | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | d | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | d | — | 4 (best 0.86) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | d | — | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | d | — | — |
| 5VHH | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | d | — | 4 (best 0.85) |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | d | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | d | — | 4 (best 0.89) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | d | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | d | — | 4 (best 0.88) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | d | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | d | — | 2 (best 0.83) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | d | — | 1 (best 0.81) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | d | — | — |
| 7QY7 | Proteasome-ZFAND5 Complex Z-A state | electron microscopy | d | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | d | — | 1 (best 0.83) |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | d | — | 2 (best 0.79) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | d | — | — |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | d | — | — |
| 9E8L | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral staircase | electron microscopy | d | — | 1 (best 0.80) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | d | — | 1 (best 0.79) |
| P48556 | AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 8 (P48556) | predicted | A | — | 4 (best 0.64) |
Experiment against prediction
- 9E8L chain d against the predicted model P48556: TM-score 0.85, RMSD 1.91 Å
- 9E8Q chain d against the predicted model P48556: TM-score 0.82, RMSD 2.11 Å
- 8JRI chain d against the predicted model P48556: TM-score 0.81, RMSD 2.26 Å
- 6WJN chain d against the predicted model P48556: TM-score 0.80, RMSD 2.56 Å
- 5T0J chain d against the predicted model P48556: TM-score 0.80, RMSD 2.38 Å
- 6MSK chain d against the predicted model P48556: TM-score 0.80, RMSD 2.44 Å
- 7QY7 chain d against the predicted model P48556: TM-score 0.80, RMSD 2.46 Å
- 5T0G chain d against the predicted model P48556: TM-score 0.80, RMSD 2.46 Å
- 5T0G chain d against the predicted model P48556: TM-score 0.80, RMSD 2.46 Å
- 5VFR chain d against the predicted model P48556: TM-score 0.80, RMSD 2.58 Å
Elsewhere
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