UniProt P62195
26S proteasome regulatory subunit 8 (P62195)
26S proteasome regulatory subunit 8 (UniProt P62195): 53 experimental structures on GenesisL1, 4 ligands bound, 103 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P62195
- Protein
- 26S proteasome regulatory subunit 8
- Experimental structures
- 53
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 103 · 22 records with a druggable one
Structures
53 records of P62195 in the MolNFT archive: 53 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KRK | Solution NMR Structure of 26S protease regulatory subunit 8 from H.sapiens, Northeast Structural… | solution nmr | A | — | — |
| 2KRK | Solution NMR structure of 26S protease regulatory subunit 8 from H.SAPIENS, northeast structural… | solution nmr | A | — | — |
| 3KW6 | Crystal Structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. Northeast… | x-ray diffraction | A | — | — |
| 3KW6 | Crystal structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. northeast… | x-ray diffraction | A | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | J | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | J, x | ADP | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | J | ATP, ADP | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | J | — | — |
| 5M32 | Human 26S proteasome in complex with Oprozomib | electron microscopy | h | ADP | 4 (best 0.82) |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | h | ADP | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | C | ATP | 4 (best 0.88) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | C | ATP | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | C | ADP | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | C | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | C | — | 5 (best 0.86) |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | C | — | — |
| 5VFQ | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | C | AGS | 3 (best 0.84) |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | C | AGS | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | C | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | C | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 5 (best 0.87) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHH | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 6 (best 0.87) |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 5 (best 0.82) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHJ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHM | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHN | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHO | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 1 (best 0.69) |
| 5VHO | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHP | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHQ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 1 (best 0.65) |
| 5VHQ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHR | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 4 (best 0.80) |
| 5VHR | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | C | — | 4 (best 0.83) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | C | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | C | ATP, MG, ADP | 4 (best 0.84) |
| 6MSJ | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | C | ATP, MG | 4 (best 0.86) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | C | ATP, MG | 8 (best 0.85) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | C | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | C | ATP, MG, ADP | 6 (best 0.86) |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | C | ATP | 5 (best 0.83) |
| 7W3H | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | electron microscopy | C | ATP, MG | 5 (best 0.81) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | C | ADP | — |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | C | ATP, ADP | 4 (best 0.83) |
| 9E8I | Human proteasome in resting state conformation bound to TXNL1 in Forward conformation | electron microscopy | C | ATP, MG, ADP | 4 (best 0.85) |
| 9E8L | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral staircase | electron microscopy | C | ADP, MG | 7 (best 0.86) |
| 9E8N | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt3 at top of spiral staircase | electron microscopy | C | ADP | 7 (best 0.80) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | C | ATP, MG | 7 (best 0.81) |
| P62195 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 8 (P62195) | — | — | — |
Ligands
Elsewhere
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