MolNFT v1 · #317114 · protein
AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 8 (P48556)
P48556: “AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 8 (P48556)”. 4 pockets (best druggability 0.64). MolNFT v1 #317114 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P48556
- Type
- protein
- Length
- 350 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb4D2d9c96b0D792d0b77e7147D724cc1F801ae58
- Molecule
- 26S proteasome non-ATPase regulatory subunit 8
- UniProt
- P48556
- Pockets
- 4 · best druggability 0.64
Structure
1 distinct chain · 54% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome non-ATPase regulatory subunit 8 | protein | 350 | 54% helix, 2% strand | P48556 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.64 | 0.89 | 23 | empty |
| 2 | 108 | 0.55 | 0.83 | 21 | empty |
| 3 | 86 | 0.41 | 0.78 | 16 | empty |
| 4 | 55 | 0.29 | 0.75 | 11 | empty |
Compared structures
- 9E8L · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral… · an experimental structure of the same protein · chain A against d, TM-score 0.66
- 5L4K · The human 26S proteasome lid · an experimental structure of the same protein · chain A against T, TM-score 0.63
- 5T0J · Structural basis for dynamic regulation of the human 26S proteasome · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 7QY7 · Proteasome-ZFAND5 Complex Z-A state · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 5T0G · Structural basis for dynamic regulation of the human 26S proteasome · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 5T0G · Structural basis for dynamic regulation of the human 26S proteasome · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 5VFR · Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated… · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 6MSK · Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 6WJN · Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3… · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 5T0I · Structural basis for dynamic regulation of the human 26S proteasome · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 5VFU · Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated… · an experimental structure of the same protein · chain A against d, TM-score 0.60
- 9E8Q · Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase · an experimental structure of the same protein · chain A against d, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48556
- Elsewhere: UniProt P48556 · AlphaFold DB P48556
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