Research workbench
AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 8 (P48556)
Analyse AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P48556
- Type
- protein
- Length
- 350 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb4D2d9c96b0D792d0b77e7147D724cc1F801ae58
- Molecule
- 26S proteasome non-ATPase regulatory subunit 8
- UniProt
- P48556
- Pockets
- 4 · best druggability 0.64
Structure
1 distinct chain · 54% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome non-ATPase regulatory subunit 8 | protein | 350 | 54% helix, 2% strand | P48556 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.64 | 0.89 | 23 | empty |
| 2 | 108 | 0.55 | 0.83 | 21 | empty |
| 3 | 86 | 0.41 | 0.78 | 16 | empty |
| 4 | 55 | 0.29 | 0.75 | 11 | empty |
Compared structures
- 8USC · Nub1/Fat10-processing human 26S proteasome · an experimental structure of the same protein · chain A against d, TM-score 0.66
- 9E8L · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral… · an experimental structure of the same protein · chain A against d, TM-score 0.66
- 9E8N · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt3 at top of spiral… · an experimental structure of the same protein · chain A against d, TM-score 0.65
- 8USB · Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1 · an experimental structure of the same protein · chain A against d, TM-score 0.65
- 9E8H · Human proteasome in resting state conformation bound to TXNL1 in backward conformation · an experimental structure of the same protein · chain A against d, TM-score 0.65
- 9E8I · Human proteasome in resting state conformation bound to TXNL1 in Forward conformation · an experimental structure of the same protein · chain A against d, TM-score 0.65
- 9E8G · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt5 at top of spiral… · an experimental structure of the same protein · chain A against d, TM-score 0.65
- 9E8J · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt1 at top of spiral… · an experimental structure of the same protein · chain A against d, TM-score 0.64
- 9E8K · Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt6 at top of spiral… · an experimental structure of the same protein · chain A against d, TM-score 0.64
- 5L4K · The human 26S proteasome lid · an experimental structure of the same protein · chain A against T, TM-score 0.63
- 5L4K · The human 26S proteasome lid · an experimental structure of the same protein · chain A against T, TM-score 0.63
- 8JRT · Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) bound to… · an experimental structure of the same protein · chain A against d, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48556
- Elsewhere: UniProt P48556 · AlphaFold DB P48556
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.