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Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)

Analyse Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5O9Z
Type
protein + RNA
Length
13,187 residues
Chains
57
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q6P2Q9, Q15029, O75643, Q96DI7, O43395, O43172, O94906, Q8WWY3, Q8NAV1, P83876, P55081, Q2TAY7, O43447, Q96NC0, P55769, O43290, O75554, Q13123, P62316, P62306, P62304, P62308, P62318, P14678, P62314, Q9Y333, P62310, Q9Y4Z0, Q9Y4Y9, P62312, Q9UK45, O95777, O75533, Q15393, Q9BWJ5, Q7RTV0, P09661, P08579

Structure

electron microscopy · 56 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein2190—Q6P2Q9
B—protein844—Q15029
C—protein1693—O75643
D—protein302—Q96DI7
E—protein219—O43395
F—protein420—O43172
G—protein804—O94906
H—protein413—Q8WWY3
I—protein176—Q8NAV1
J—protein135—P83876
K—protein45—P55081
L—protein459—Q2TAY7
M—protein169—O43447
N—protein56—Q96NC0
O—protein126—P55769
P—protein91—O43290
Q—protein75—O75554
R—protein16—Q13123
a—protein78—P62316
b—protein73—P62306
c, j—protein78—P62304
d—protein69—P62308
e—protein78—P62318
f—protein64—P14678
g—protein93—P62314
h—protein74—P62316
i—protein71—P62306
k—protein73—P62308
l—protein71—P62318
m—protein64—P14678
n—protein82—P62314
o—protein90—Q9Y333
p—protein73—P62310
q—protein80—Q9Y4Z0
r—protein76—Q9Y4Y9
s—protein69—P62312
t—protein79—Q9UK45
u—protein62—O95777
v—protein806—O75533
w—protein1140—Q15393
x—protein54—Q9BWJ5
y—protein89—Q7RTV0
z—protein162—P09661
1—protein94—P08579
S—protein87—P62316
T—protein74—P62306
U—protein79—P62304
V—protein74—P62308
W—protein80—P62318
X—protein71—P14678
Z—protein82—P62314
Y—rna46——
2—rna100——
4—rna137——
5—rna114——
6—rna90——

Compared structures

  • 5O9Z · Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) · the same entry in another collection · chain C against C, TM-score 1.00

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