UniProt Q7RTV0
PHD finger-like domain-containing protein 5A (Q7RTV0)
PHD finger-like domain-containing protein 5A (UniProt Q7RTV0): 38 experimental structures on GenesisL1, 8 ligands bound, 15 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q7RTV0
- Protein
- PHD finger-like domain-containing protein 5A
- Experimental structures
- 38
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 15 · 5 records with a druggable one
Structures
38 records of Q7RTV0 in the MolNFT archive: 38 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IFE | Crystal structure of the human SF3b core complex | x-ray diffraction | D | ZN | — |
| 5IFE | Crystal structure of the human SF3B core complex | x-ray diffraction | D | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | y | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | y | — | — |
| 5SYB | Crystal structure of human PHF5A | x-ray diffraction | A, B | ZN | — |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | 6 | ZN | — |
| 5ZYA | SF3B spliceosomal complex bound to E7107 | electron microscopy | D | 9B0, ZN | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | 6 | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | 6 | — | — |
| 6EN4 | SF3B core in complex with a splicing modulator | x-ray diffraction | D | ZN, BGZ | — |
| 6FF4 | human Bact spliceosome core structure | electron microscopy | y | ZN | 3 (best 0.83) |
| 6FF4 | Human bact spliceosome core structure | electron microscopy | y | ZN | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | y | ZN | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | BP | ZN | 2 (best 0.79) |
| 6Y50 | 5'domain of human 17S U2 snRNP | electron microscopy | y | ZN | 3 (best 0.78) |
| 6Y50 | 5'DOMAIN of human 17S U2 snrnp | electron microscopy | y | ZN | — |
| 6Y5Q | Human 17S U2 snrnp | electron microscopy | y | — | — |
| 7ABH | Human pre-bact-2 spliceosome (SF3B/U2 snrnp portion) | electron microscopy | y | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | y | — | — |
| 7B0I | Structure of a minimal SF3B core in complex with spliceostatin A (form II) | x-ray diffraction | D | SJT, ZN | — |
| 7B0I | Structure of a minimal SF3B core in complex with spliceostatin a (form II) | x-ray diffraction | D | SJT, ZN | — |
| 7B91 | Structure of a minimal SF3B core in complex with pladienolide D (form I) | x-ray diffraction | D | T2Z, ZN | — |
| 7B92 | Structure of a minimal SF3B core in complex with sudemycin D6 (form II) | x-ray diffraction | D | ZN, T2W | — |
| 7B9C | Structure of a minimal SF3B core in complex with spliceostatin a (form I) | x-ray diffraction | D | ZN, SCN, SJT | — |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | 6 | ZN | — |
| 7EVN | The cryo-EM structure of the DDX42-SF3b complex | electron microscopy | D | ZN | — |
| 7EVN | The cryo-EM structure of the DDX42-SF3B complex | electron microscopy | D | ZN | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snRNP | electron microscopy | 6 | 9B0, ZN | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snrnp | electron microscopy | 6 | 9B0, ZN | — |
| 7OMF | Structure of a minimal SF3B core in complex with sudemycin D6 (form I) | x-ray diffraction | D | ZN, T2W, SCN | — |
| 7ONB | Structure of the U2 5' module of the A3'-ssa complex | electron microscopy | D | SJT, ZN | — |
| 7OPI | Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E (form I) | x-ray diffraction | D | 07I, ZN | — |
| 7Q3L | Human 17S U2 snrnp 5' domain | electron microscopy | G | ZN | — |
| 7Q4O | Substrate-bound a-like U2 snrnp | electron microscopy | G | ZN | — |
| 7Q4P | U2 snrnp after ATP-dependent remodelling | electron microscopy | G | ZN | — |
| 7VPX | The cryo-EM structure of the human pre-A complex | electron microscopy | 6 | ZN, SJT | 3 (best 0.82) |
| 8HK1 | The cryo-EM structure of human pre-17S U2 snRNP | electron microscopy | 6 | 9B0, ZN | 4 (best 0.83) |
| Q7RTV0 | AlphaFold monomer V2.0 prediction for phd finger-like domain- containing protein 5A (Q7RTV0) | — | — | — |
Ligands
- ZN · Zinc ion · in 29 records
- SJT · spliceostatin A (form II) · in 5 records
- 9B0 · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R}, 3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate · in 4 records
- SCN · Thiocyanate ion · in 2 records
- T2W · [(~{Z},2~{S})-5-[[4-[(2~{E},4~{E})-3-methyl-5-[(2~{S}, 4~{R})-4,6,6-trimethyl-4-oxidanyl-oxan-2-yl]penta-2,4-dienyl]cyclohexyl]amino]-5-oxidanylidene-pent-3-en-2-yl] ~{N}-methylcarbamate · in 2 records
- 07I · Spliceostatin E (form I) · in 1 record
- BGZ · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{S})-6-methyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate · in 1 record
- T2Z · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R}, 3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate · in 1 record
Elsewhere
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