UniProt Q6P2Q9
Pre-mRNA-processing-splicing factor 8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (UniProt Q6P2Q9): 131 experimental structures on GenesisL1, 7 ligands bound, 650 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q6P2Q9
- Protein
- Pre-mRNA-processing-splicing factor 8
- Experimental structures
- 131
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 650 · 68 records with a druggable one
Structures
131 records of Q6P2Q9 in the MolNFT archive: 131 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3E9L | Crystal Structure of Human Prp8, Residues 1755-2016 | x-ray diffraction | A | — | — |
| 3E9L | Crystal structure of human PRP8, residues 1755-2016 | x-ray diffraction | A | — | — |
| 3ENB | Crystal Structure of PRP8 core domain IV | x-ray diffraction | A, B | — | — |
| 3ENB | Crystal structure of PRP8 core domain IV | x-ray diffraction | A, B | — | — |
| 3JCR | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | electron microscopy | A | — | — |
| 3JCR | 3D structure determination of the HUMAN*U4/U6.U5* tri-snrnp complex | electron microscopy | A | — | — |
| 3LRU | hPRP8 Non-Native Subdomain | x-ray diffraction | A, B | — | — |
| 3LRU | HPRP8 non-native subdomain | x-ray diffraction | A, B | — | — |
| 4JK7 | Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JK7 | Open and closed forms of wild-type human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JK8 | Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JK8 | Open and closed forms of R1865A human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JK9 | Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion | x-ray diffraction | A, B | — | — |
| 4JK9 | Open and closed forms of wild-type human PRP8 RNase H-like domain with bound co ion | x-ray diffraction | A, B | — | — |
| 4JKA | Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion | x-ray diffraction | A, B | — | — |
| 4JKA | Open and closed forms of R1865A human PRP8 RNase H-like domain with bound co ion | x-ray diffraction | A, B | — | — |
| 4JKB | Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JKB | Open and closed forms of V1788D human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JKC | Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JKC | Open and closed forms of T1800E human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JKD | Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JKD | Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JKE | Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JKE | Open and closed forms of T1789P human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JKF | Open and closed forms of T1791P+R1865A human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JKF | Open and closed forms of T1791P+R1865A human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4JKG | Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain with bound… | x-ray diffraction | A, B | — | — |
| 4JKG | Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain with bound… | x-ray diffraction | A, B | — | — |
| 4JKH | Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion | x-ray diffraction | A, B | — | — |
| 4JKH | Open and closed forms of D1781E human PRP8 RNase H-like domain with bound mg ion | x-ray diffraction | A, B | — | — |
| 4KIT | Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain | x-ray diffraction | C | — | — |
| 4KIT | Crystal structure of human BRR2 in complex with the PRP8 JAB1/MPN domain | x-ray diffraction | C | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | A | — | 4 (best 0.83) |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | A | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | A | — | 7 (best 0.83) |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | A | — | — |
| 5XJC | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | electron microscopy | A | IHP, GTP | — |
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | A | IHP, GTP, MG | 10 (best 0.88) |
| 5Z57 | Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | electron microscopy | A | IHP, ALA, GTP, MG | 10 (best 0.88) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | electron microscopy | A | IHP, GTP, MG | 12 (best 0.86) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | A | IHP, GTP, MG | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | A | GTP | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | A | GTP | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | A | IHP, GTP | 15 (best 0.87) |
| 6FF4 | human Bact spliceosome core structure | electron microscopy | A | IHP, GTP | 11 (best 0.88) |
| 6FF4 | Human bact spliceosome core structure | electron microscopy | A | IHP, GTP | — |
| 6FF7 | human Bact spliceosome core structure | electron microscopy | A | IHP | 5 (best 0.82) |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | A | IHP | — |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | electron microscopy | A | IHP, GTP, MG | 11 (best 0.89) |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström | electron microscopy | A | IHP, GTP | — |
| 6ID0 | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9… | electron microscopy | A | IHP, GTP, MG | — |
| 6ID0 | Cryo-EM structure of a human intron lariat spliceosome prior to PRP43 loaded (ILS1 complex) at 2.9… | electron microscopy | A | IHP, GTP, MG | — |
| 6ID1 | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9… | electron microscopy | A | IHP, GTP, MG | 13 (best 0.89) |
| 6ID1 | Cryo-EM structure of a human intron lariat spliceosome after PRP43 loaded (ILS2 complex) at 2.9… | electron microscopy | A | IHP, GTP, MG | — |
| 6QW6 | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | electron microscopy | 5A | IHP, GTP | 13 (best 0.86) |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | 5A | GTP, IHP | 8 (best 0.86) |
| 6S8Q | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 | x-ray diffraction | J | — | 6 (best 0.84) |
| 6S8Q | Human BRR2 helicase region in complex with C-tail deleted JAB1 | x-ray diffraction | J | — | — |
| 6S9I | Human Brr2 Helicase Region D534C/N1866C in complex with C-tail deleted Jab1 | x-ray diffraction | J | — | 5 (best 0.84) |
| 6S9I | Human BRR2 helicase region D534C/N1866C in complex with C-tail deleted JAB1 | x-ray diffraction | J | — | — |
71 records more on the page itself.
Ligands
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