UniProt O94906
Pre-mRNA-processing factor 6 (O94906)
Pre-mRNA-processing factor 6 (UniProt O94906): 32 experimental structures and 1 predicted model on GenesisL1, 114 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O94906
- Protein
- Pre-mRNA-processing factor 6
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 114 · 26 records with a druggable one
Structures
33 records of O94906 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCR | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | electron microscopy | G | — | — |
| 3JCR | 3D structure determination of the HUMAN*U4/U6.U5* tri-snrnp complex | electron microscopy | G | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | G | — | 3 (best 0.80) |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | G | — | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | N | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | N | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | N | — | 5 (best 0.86) |
| 6QW6 | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | electron microscopy | 5J | — | 4 (best 0.83) |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 4G | — | 5 (best 0.83) |
| 8H6J | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | electron microscopy | 4G | — | 3 (best 0.83) |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 4G | — | 7 (best 0.86) |
| 8H6L | Cryo-EM structure of human exon-defined spliceosome in the early B state. | electron microscopy | 4G | — | 7 (best 0.86) |
| 8Q7N | cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | electron microscopy | N | — | 5 (best 0.87) |
| 8Q7V | Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1) | electron microscopy | F | — | 2 (best 0.82) |
| 8Q7W | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3) | electron microscopy | F | — | 2 (best 0.82) |
| 8Q7X | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4) | electron microscopy | F | — | 2 (best 0.82) |
| 8Q91 | Structure of the human 20S U5 snRNP core | electron microscopy | E | — | 2 (best 0.85) |
| 8QO9 | Cryo-EM structure of a human spliceosomal B complex protomer | electron microscopy | N | — | — |
| 8QP8 | Cryo-EM Structure of Pre-B Complex (core part) | electron microscopy | N | — | 3 (best 0.83) |
| 8QP9 | Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | electron microscopy | N | — | 4 (best 0.85) |
| 8QPA | Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | electron microscopy | N | — | 10 (best 0.85) |
| 8QPB | Cryo-EM Structure of Pre-B+ATP Complex (core part) | electron microscopy | N | — | 11 (best 0.88) |
| 8QPE | Cryo-EM Structure of Pre-B-like Complex (core part) | electron microscopy | N | — | 12 (best 0.88) |
| 8QPK | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | electron microscopy | N | — | 5 (best 0.83) |
| 8QXD | Cryo-EM structure of the cross-exon pre-B complex | electron microscopy | N | — | 3 (best 0.85) |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | N | — | 3 (best 0.83) |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | N | — | 1 (best 0.83) |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | N | — | 1 (best 0.81) |
| 8R0A | Cryo-EM structure of the cross-exon pre-B+5'ss complex | electron microscopy | N | — | 2 (best 0.82) |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | N | — | — |
| 8RM5 | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | electron microscopy | N | — | 5 (best 0.84) |
| 8Y6O | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP… | electron microscopy | G | — | 4 (best 0.86) |
| O94906 | AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 6 (O94906) | predicted | A | — | 3 (best 0.78) |
Experiment against prediction
- 8Q7W chain F against the predicted model O94906: TM-score 0.82, RMSD 0.34 Å
- 8Q7X chain F against the predicted model O94906: TM-score 0.82, RMSD 0.34 Å
- 8Q7V chain F against the predicted model O94906: TM-score 0.81, RMSD 0.36 Å
- 6QW6 chain 5J against the predicted model O94906: TM-score 0.81, RMSD 2.49 Å
- 8QXD chain N against the predicted model O94906: TM-score 0.81, RMSD 2.07 Å
- 8R08 chain N against the predicted model O94906: TM-score 0.81, RMSD 2.07 Å
- 8Y6O chain G against the predicted model O94906: TM-score 0.80, RMSD 2.62 Å
- 8R0A chain N against the predicted model O94906: TM-score 0.77, RMSD 3.36 Å
- 3JCR chain G against the predicted model O94906: TM-score 0.76, RMSD 4.61 Å
- 3JCR chain G against the predicted model O94906: TM-score 0.76, RMSD 4.61 Å
Elsewhere
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