UniProt O75533
Splicing factor 3B subunit 1 (O75533)
Splicing factor 3B subunit 1 (UniProt O75533): 79 experimental structures on GenesisL1, 6 ligands bound, 155 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O75533
- Protein
- Splicing factor 3B subunit 1
- Experimental structures
- 79
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 155 · 29 records with a druggable one
Structures
79 records of O75533 in the MolNFT archive: 79 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2F9D | 2.5 angstrom resolution structure of the spliceosomal protein p14 bound to region of SF3b155 | x-ray diffraction | P, Q | — | — |
| 2F9D | 2.5 ångström resolution structure of the spliceosomal protein P14 bound to region of SF3B155 | x-ray diffraction | P, Q | — | — |
| 2F9J | 3.0 angstrom resolution structure of a Y22M mutant of the spliceosomal protein p14 bound to a… | x-ray diffraction | P, Q | — | — |
| 2F9J | 3.0 ångström resolution structure of a Y22M mutant of the spliceosomal protein P14 bound to a… | x-ray diffraction | P, Q | — | — |
| 2FHO | NMR solution structure of the human spliceosomal protein complex p14-SF3b155 | solution nmr | A | — | — |
| 2FHO | NMR solution structure of the human spliceosomal protein complex P14- SF3B155 | solution nmr | A | — | — |
| 2PEH | Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5 | x-ray diffraction | C, D | — | — |
| 2PEH | Crystal structure of the uhm domain of human SPF45 in complex with SF3B155-ULM5 | x-ray diffraction | C, D | — | — |
| 3LQV | Branch Recognition by SF3b14 | x-ray diffraction | P, Q | — | — |
| 3LQV | Branch recognition by SF3B14 | x-ray diffraction | P, Q | — | — |
| 4OZ1 | Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5 | x-ray diffraction | C | — | — |
| 4OZ1 | Crystal structure of human caperalpha uhm bound to SF3B155 ULM5 | x-ray diffraction | C | — | — |
| 5IFE | Crystal structure of the human SF3b core complex | x-ray diffraction | C | — | — |
| 5IFE | Crystal structure of the human SF3B core complex | x-ray diffraction | C | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | v | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | v | — | — |
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | 1 | — | 2 (best 0.85) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | 1 | — | — |
| 5ZYA | SF3B spliceosomal complex bound to E7107 | electron microscopy | C | 9B0 | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | 1 | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | 1 | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | 1 | — | — |
| 6EN4 | SF3b core in complex with a splicing modulator | x-ray diffraction | C | BGZ | 11 (best 0.84) |
| 6EN4 | SF3B core in complex with a splicing modulator | x-ray diffraction | C | BGZ | — |
| 6FF4 | human Bact spliceosome core structure | electron microscopy | u | — | 6 (best 0.88) |
| 6FF4 | Human bact spliceosome core structure | electron microscopy | u | — | — |
| 6FF7 | human Bact spliceosome core structure | electron microscopy | u | — | 3 (best 0.86) |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | u | — | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | B1 | — | 2 (best 0.79) |
| 6Y50 | 5'domain of human 17S U2 snRNP | electron microscopy | u | — | 10 (best 0.85) |
| 6Y50 | 5'DOMAIN of human 17S U2 snrnp | electron microscopy | u | — | — |
| 6Y53 | human 17S U2 snRNP low resolution part | electron microscopy | u | — | 1 (best 0.52) |
| 6Y53 | Human 17S U2 snrnp low resolution part | electron microscopy | u | — | — |
| 6Y5Q | Human 17S U2 snrnp | electron microscopy | u | — | — |
| 7ABG | Human pre-Bact-1 spliceosome | electron microscopy | u | — | 1 (best 0.82) |
| 7ABH | Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion) | electron microscopy | u | — | 9 (best 0.86) |
| 7ABH | Human pre-bact-2 spliceosome (SF3B/U2 snrnp portion) | electron microscopy | u | — | — |
| 7ABI | Human pre-Bact-2 spliceosome | electron microscopy | u | — | 2 (best 0.83) |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | u | — | — |
| 7B0I | Structure of a minimal SF3B core in complex with spliceostatin A (form II) | x-ray diffraction | C | SJT | — |
| 7B0I | Structure of a minimal SF3B core in complex with spliceostatin a (form II) | x-ray diffraction | C | SJT | — |
| 7B91 | Structure of a minimal SF3B core in complex with pladienolide D (form I) | x-ray diffraction | C | T2Z | — |
| 7B92 | Structure of a minimal SF3B core in complex with sudemycin D6 (form II) | x-ray diffraction | C | T2W | — |
| 7B9C | Structure of a minimal SF3B core in complex with spliceostatin A (form I) | x-ray diffraction | C | SJT | 11 (best 0.81) |
| 7B9C | Structure of a minimal SF3B core in complex with spliceostatin a (form I) | x-ray diffraction | C | SJT | — |
| 7DVQ | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | electron microscopy | 1 | — | 7 (best 0.85) |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | 1 | — | — |
| 7EVN | The cryo-EM structure of the DDX42-SF3b complex | electron microscopy | C | — | — |
| 7EVN | The cryo-EM structure of the DDX42-SF3B complex | electron microscopy | C | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snRNP | electron microscopy | 1 | 9B0 | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snrnp | electron microscopy | 1 | 9B0 | — |
| 7OMF | Structure of a minimal SF3B core in complex with sudemycin D6 (form I) | x-ray diffraction | C | T2W | — |
| 7ONB | Structure of the U2 5' module of the A3'-ssa complex | electron microscopy | C | SJT | — |
| 7OPI | Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E (form I) | x-ray diffraction | C | 07I | 10 (best 0.79) |
| 7OPI | Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E (form I) | x-ray diffraction | C | 07I | — |
| 7Q3L | Human 17S U2 snRNP 5' domain | electron microscopy | A | — | 11 (best 0.81) |
| 7Q3L | Human 17S U2 snrnp 5' domain | electron microscopy | A | — | — |
| 7Q4O | Substrate-bound A-like U2 snRNP | electron microscopy | A | — | 13 (best 0.77) |
| 7Q4O | Substrate-bound a-like U2 snrnp | electron microscopy | A | — | — |
| 7Q4P | U2 snRNP after ATP-dependent remodelling | electron microscopy | A | — | 13 (best 0.77) |
19 records more on the page itself.
Ligands
- SJT · spliceostatin A (form II) · in 6 records
- 9B0 · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R}, 3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate · in 4 records
- 07I · Spliceostatin E (form I) · in 2 records
- BGZ · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{S})-6-methyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate · in 2 records
- T2W · [(~{Z},2~{S})-5-[[4-[(2~{E},4~{E})-3-methyl-5-[(2~{S}, 4~{R})-4,6,6-trimethyl-4-oxidanyl-oxan-2-yl]penta-2,4-dienyl]cyclohexyl]amino]-5-oxidanylidene-pent-3-en-2-yl] ~{N}-methylcarbamate · in 2 records
- T2Z · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R}, 3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate · in 1 record
Elsewhere
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