UniProt O75643
U5 small nuclear ribonucleoprotein 200 kDa helicase (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (UniProt O75643), EC 3.6.4.13: 73 experimental structures on GenesisL1, 15 ligands bound, 360 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O75643
- Protein
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- EC
- 3.6.4.13
- Experimental structures
- 73
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 360 · 35 records with a druggable one
Structures
73 records of O75643 in the MolNFT archive: 73 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCR | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | electron microscopy | C | — | — |
| 3JCR | 3D structure determination of the HUMAN*U4/U6.U5* tri-snrnp complex | electron microscopy | C | — | — |
| 4F91 | Brr2 Helicase Region | x-ray diffraction | B | — | — |
| 4F91 | BRR2 helicase region | x-ray diffraction | B | — | — |
| 4F92 | Brr2 Helicase Region S1087L | x-ray diffraction | B | — | — |
| 4F92 | BRR2 helicase region S1087L | x-ray diffraction | B | — | — |
| 4F93 | Brr2 Helicase Region S1087L, Mg-ATP | x-ray diffraction | B | — | — |
| 4F93 | BRR2 helicase region S1087L, mg-ATP | x-ray diffraction | B | — | — |
| 4KIT | Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain | x-ray diffraction | B | — | — |
| 4KIT | Crystal structure of human BRR2 in complex with the PRP8 JAB1/MPN domain | x-ray diffraction | B | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | C | — | 6 (best 0.82) |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | C | — | — |
| 5URJ | Crystal structure of human BRR2 in complex with T-3905516 | x-ray diffraction | A | 8LS | — |
| 5URK | Crystal structure of human BRR2 in complex with T-3935799 | x-ray diffraction | A | 8LP | 16 (best 0.80) |
| 5URK | Crystal structure of human BRR2 in complex with T-3935799 | x-ray diffraction | A | 8LP | — |
| 5URM | Crystal structure of human BRR2 in complex with T-1206548 | x-ray diffraction | A, B | 8LV | 20 (best 0.87) |
| 5URM | Crystal structure of human BRR2 in complex with T-1206548 | x-ray diffraction | A, B | 8LV | 20 (best 0.87) |
| 5XJC | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | electron microscopy | D | ADP, MG | — |
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | D | — | 1 (best 0.83) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | D | — | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | D | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | D | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | D | — | 1 (best 0.76) |
| 6FF7 | human Bact spliceosome core structure | electron microscopy | r | ADP | 3 (best 0.84) |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | r | ADP | — |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström | electron microscopy | D | — | — |
| 6QW6 | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | electron microscopy | 5B | — | 6 (best 0.86) |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | 5B | — | 5 (best 0.85) |
| 6S8O | Human Brr2 Helicase Region M641C/A1582C | x-ray diffraction | B | — | 20 (best 0.86) |
| 6S8O | Human BRR2 helicase region M641C/A1582C | x-ray diffraction | B | — | — |
| 6S8Q | Human BRR2 helicase region in complex with C-tail deleted JAB1 | x-ray diffraction | B | SO4 | — |
| 6S9I | Human Brr2 Helicase Region D534C/N1866C in complex with C-tail deleted Jab1 | x-ray diffraction | B | — | 19 (best 0.84) |
| 6S9I | Human BRR2 helicase region D534C/N1866C in complex with C-tail deleted JAB1 | x-ray diffraction | B | — | — |
| 7A5P | Human C Complex Spliceosome - Medium-resolution PERIPHERY | electron microscopy | q | — | — |
| 7A5P | Human C complex spliceosome - medium-resolution periphery | electron microscopy | q | — | — |
| 7ABG | Human pre-Bact-1 spliceosome | electron microscopy | s | — | 2 (best 0.86) |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | s | — | — |
| 7BDI | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS | x-ray diffraction | B | AGS, MG | 19 (best 0.82) |
| 7BDI | Human BRR2 helicase region in complex with C-tail deleted JAB1 and atpgammas | x-ray diffraction | B | AGS, MG | — |
| 7BDJ | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS | x-ray diffraction | B | TGB, MG | 19 (best 0.85) |
| 7BDJ | Human BRR2 helicase region in complex with C-tail deleted JAB1 and mant-atpgammas | x-ray diffraction | B | TGB, MG | — |
| 7BDK | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP | x-ray diffraction | B | ADP, MG | 18 (best 0.85) |
| 7BDK | Human BRR2 helicase region in complex with C-tail deleted JAB1 and ADP | x-ray diffraction | B | ADP, MG | — |
| 7BDL | Human BRR2 helicase region in complex with C-tail deleted JAB1 and mant-ADP | x-ray diffraction | B | TG8, MG | — |
| 7DVQ | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | electron microscopy | D | — | 2 (best 0.83) |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | D | — | — |
| 7OS1 | Cryo-EM structure of Brr2 in complex with Fbp21 | electron microscopy | B | — | 20 (best 0.82) |
| 7OS1 | Cryo-EM structure of BRR2 in complex with FBP21 | electron microscopy | B | — | — |
| 7OS2 | Cryo-EM structure of Brr2 in complex with Jab1/MPN and C9ORF78 | electron microscopy | B | — | 19 (best 0.85) |
| 7OS2 | Cryo-EM structure of BRR2 in complex with JAB1/MPN and C9ORF78 | electron microscopy | B | — | — |
| 7PX3 | Structure of U5 snrnp assembly and recycling factor TSSC4 in complex with BRR2 and JAB1 domain of… | electron microscopy | B | — | — |
| 7W5B | The cryo-EM structure of human C* complex | electron microscopy | D | — | 4 (best 0.84) |
| 8BC8 | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 18 | x-ray diffraction | B | QB6 | 19 (best 0.85) |
| 8BCA | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 26 | x-ray diffraction | B | Q96 | 19 (best 0.83) |
| 8BCB | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 34 | x-ray diffraction | B | SAN | 19 (best 0.83) |
| 8BCE | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 76 | x-ray diffraction | B | B09 | 19 (best 0.83) |
| 8BCG | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 86 | x-ray diffraction | B | Q9I | — |
| 8BCH | Human Brr2 Helicase Region in complex with Sulfaguanidine | x-ray diffraction | B | QA9 | 18 (best 0.85) |
| 8C6J | Human spliceosomal PM5 C* complex | electron microscopy | B | — | — |
| 8CH6 | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius… | electron microscopy | c | — | 2 (best 0.85) |
13 records more on the page itself.
Ligands
- MG · Magnesium ion · in 8 records
- ADP · Adenosine-5'-diphosphate · in 5 records
- 8LP · 6-benzyl-3-[3-(benzyloxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione · in 2 records
- 8LV · 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid · in 2 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
- TGB · [[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-[2-(methylamino)phenyl]carbonyloxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphinic acid · in 2 records
- 8LS · 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione · in 1 record
- B09 · N-methoxybenzenesulfonamide · in 1 record
- Q96 · 3-azanyl-~{N}-methyl-4-(methylamino)benzenesulfonamide · in 1 record
- Q9I · 4-chloranyl-~{N}-methoxy-~{N}-methyl-benzenesulfonamide · in 1 record
- QA9 · 1-(4-aminophenyl)sulfonylguanidine · in 1 record
- QB6 · 3-azanyl-4-oxidanyl-benzenesulfonamide · in 1 record
- SAN · Sulfanilamide · in 1 record
- SO4 · Sulfate ion · in 1 record
- TG8 · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-2-[[oxidanyl(phosphonooxy) phosphoryl]oxymethyl]oxolan-3-yl] 2-(methylamino) benzoate · in 1 record
Elsewhere
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