UniProt Q8NAV1
Pre-mRNA-splicing factor 38A (Q8NAV1)
Pre-mRNA-splicing factor 38A (UniProt Q8NAV1): 20 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8NAV1
- Protein
- Pre-mRNA-splicing factor 38A
- Experimental structures
- 20
- Predicted models
- 1
- Pockets
- 17 · 9 records with a druggable one
Structures
21 records of Q8NAV1 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4RZ9 | Pre-mRNA-splicing factor 38A AS 1-179 | x-ray diffraction | A | — | — |
| 4RZ9 | Pre-mRNA-splicing factor 38A as 1-179 | x-ray diffraction | A | — | — |
| 4RZA | Pre-mRNA-splicing factor 38A AS 1-205 | x-ray diffraction | A | — | — |
| 4RZA | Pre-mRNA-splicing factor 38A as 1-205 | x-ray diffraction | A | — | — |
| 5F5S | Crystal structure of the Prp38-MFAP1 complex of Homo sapiens | x-ray diffraction | A | — | — |
| 5F5S | Crystal structure of the PRP38-MFAP1 complex of homo sapiens | x-ray diffraction | A | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | I | — | 1 (best 0.81) |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | I | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | Z | — | 1 (best 0.82) |
| 7AAV | Human pre-Bact-2 spliceosome core structure | electron microscopy | I | — | 3 (best 0.83) |
| 7AAV | Human pre-bact-2 spliceosome core structure | electron microscopy | I | — | — |
| 7ABF | Human pre-Bact-1 spliceosome core structure | electron microscopy | I | — | 2 (best 0.89) |
| 7ABG | Human pre-Bact-1 spliceosome | electron microscopy | I | — | — |
| 7ABI | Human pre-Bact-2 spliceosome | electron microscopy | I | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | I | — | — |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 4L | — | 2 (best 0.88) |
| 8Q7N | cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | electron microscopy | I | — | 1 (best 0.91) |
| 8QO9 | Cryo-EM structure of a human spliceosomal B complex protomer | electron microscopy | I | — | 1 (best 0.82) |
| 8QPE | Cryo-EM Structure of Pre-B-like Complex (core part) | electron microscopy | I | — | 1 (best 0.86) |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | I | — | 2 (best 0.82) |
| Q8NAV1 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor 38A (Q8NAV1) | predicted | A | — | 3 (best 0.33) |
Experiment against prediction
- 4RZ9 chain A against the predicted model Q8NAV1: TM-score 0.99, RMSD 0.46 Å
- 4RZ9 chain A against the predicted model Q8NAV1: TM-score 0.99, RMSD 0.46 Å
- 8Q7N chain I against the predicted model Q8NAV1: TM-score 0.98, RMSD 0.75 Å
- 8QPE chain I against the predicted model Q8NAV1: TM-score 0.98, RMSD 0.75 Å
- 8QZS chain I against the predicted model Q8NAV1: TM-score 0.98, RMSD 0.75 Å
- 5F5S chain A against the predicted model Q8NAV1: TM-score 0.98, RMSD 0.79 Å
- 5F5S chain A against the predicted model Q8NAV1: TM-score 0.98, RMSD 0.79 Å
- 8QO9 chain I against the predicted model Q8NAV1: TM-score 0.98, RMSD 0.81 Å
- 8H6K chain 4L against the predicted model Q8NAV1: TM-score 0.97, RMSD 0.89 Å
- 7ABG chain I against the predicted model Q8NAV1: TM-score 0.95, RMSD 1.15 Å
Elsewhere
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