UniProt O43172
U4/U6 small nuclear ribonucleoprotein Prp4 (O43172)
U4/U6 small nuclear ribonucleoprotein Prp4 (UniProt O43172): 27 experimental structures and 1 predicted model on GenesisL1, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43172
- Protein
- U4/U6 small nuclear ribonucleoprotein Prp4
- Experimental structures
- 27
- Predicted models
- 1
- Pockets
- 36 · 18 records with a druggable one
Structures
28 records of O43172 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MZW | Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K… | x-ray diffraction | B | — | — |
| 1MZW | Crystal structure of a U4/U6 snrnp complex between human spliceosomal cyclophilin H and a U4/U6-60K… | x-ray diffraction | B | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | F | — | 2 (best 0.82) |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | F | — | 2 (best 0.82) |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | K | — | 1 (best 0.71) |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | K | — | 1 (best 0.71) |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | K | — | — |
| 6QW6 | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | electron microscopy | 4B | — | 1 (best 0.84) |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | 4B | — | 1 (best 0.79) |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 4C | — | 1 (best 0.80) |
| 8H6J | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | electron microscopy | 4C | — | 3 (best 0.82) |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 4C | — | 4 (best 0.81) |
| 8H6L | Cryo-EM structure of human exon-defined spliceosome in the early B state. | electron microscopy | 4C | — | 3 (best 0.81) |
| 8Q7N | cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | electron microscopy | F | — | 3 (best 0.84) |
| 8QO9 | Cryo-EM structure of a human spliceosomal B complex protomer | electron microscopy | F | — | — |
| 8QOZ | Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | electron microscopy | F | — | — |
| 8QPA | Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | electron microscopy | F | — | — |
| 8QPB | Cryo-EM Structure of Pre-B+ATP Complex (core part) | electron microscopy | F | — | 1 (best 0.69) |
| 8QPE | Cryo-EM Structure of Pre-B-like Complex (core part) | electron microscopy | F | — | 3 (best 0.84) |
| 8QXD | Cryo-EM structure of the cross-exon pre-B complex | electron microscopy | F | — | 1 (best 0.83) |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | F | — | — |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | 4B | — | — |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | F | — | — |
| 8R0A | Cryo-EM structure of the cross-exon pre-B+5'ss complex | electron microscopy | F | — | 1 (best 0.80) |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | F | — | — |
| 8RM5 | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | electron microscopy | F | — | 1 (best 0.82) |
| 8Y6O | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP… | electron microscopy | M | — | 2 (best 0.80) |
| O43172 | AlphaFold monomer V2.0 prediction for U4/U6 small nuclear ribonucleoprotein PRP4 (O43172) | predicted | A | — | 5 (best 0.76) |
Experiment against prediction
- 8Y6O chain M against the predicted model O43172: TM-score 0.99, RMSD 0.68 Å
- 6QW6 chain 4B against the predicted model O43172: TM-score 0.99, RMSD 0.67 Å
- 6QX9 chain 4B against the predicted model O43172: TM-score 0.99, RMSD 0.67 Å
- 8H6J chain 4C against the predicted model O43172: TM-score 0.99, RMSD 0.68 Å
- 8H6E chain 4C against the predicted model O43172: TM-score 0.99, RMSD 0.68 Å
- 8QXD chain F against the predicted model O43172: TM-score 0.99, RMSD 0.85 Å
- 8R0A chain F against the predicted model O43172: TM-score 0.98, RMSD 0.86 Å
- 8R08 chain 4B against the predicted model O43172: TM-score 0.98, RMSD 0.95 Å
- 6AH0 chain K against the predicted model O43172: TM-score 0.96, RMSD 1.41 Å
- 6AH0 chain K against the predicted model O43172: TM-score 0.96, RMSD 1.41 Å
Elsewhere
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