MolNFT v1 · #15279 · protein
Crystal structure of a U4/U6 snrnp complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide
1MZW · U-snrnp-associated cyclophilin: “Crystal structure of a U4/U6 snrnp complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #15279 on GenesisL1: 3D…
- PDB
- 1MZW
- Type
- protein
- Length
- 204 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U-snrnp-associated cyclophilin; U4/U6 snrnp 60KDA protein
- UniProt
- O43447, O43172
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U-snrnp-associated cyclophilin | protein | 173 | 15% helix, 33% strand | O43447 |
| B | U4/U6 snrnp 60KDA protein | protein | 31 | 58% helix, 6% strand | O43172 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.33 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 462 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1MZW · Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a… · the same entry in another collection · chain A against A, TM-score 1.00
- O43447 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase H (O43447) · a predicted model of the same protein · chain A against A, TM-score 0.98
- O43172 · AlphaFold monomer V2.0 prediction for U4/U6 small nuclear ribonucleoprotein PRP4 (O43172) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43447
- Every structure of UniProt O43172
- Elsewhere: RCSB PDB 1MZW · PDBe 1MZW · UniProt O43447 · UniProt O43172
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