UniProt Q2TAY7
WD40 repeat-containing protein SMU1 (Q2TAY7)
WD40 repeat-containing protein SMU1 (UniProt Q2TAY7): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q2TAY7
- Protein
- WD40 repeat-containing protein SMU1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 30 · 7 records with a druggable one
Structures
14 records of Q2TAY7 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | L | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | L | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | Y | — | 1 (best 0.76) |
| 6Q8F | Nterminal domain of human SMU1 | x-ray diffraction | A, B | CL | 3 (best 0.61) |
| 6Q8F | Nterminal domain of human SMU1 | x-ray diffraction | A, B | CL | — |
| 6Q8I | Nterminal domain of human SMU1 in complex with human REDmid | x-ray diffraction | A, B, E, F, I, J, M, N | — | 20 (best 0.77) |
| 6Q8I | Nterminal domain of human SMU1 in complex with human redmid | x-ray diffraction | A, B, E, F, I, J, M, N | — | — |
| 6Q8J | Nterminal domain of human SMU1 in complex with LSP641 | x-ray diffraction | A | XS4 | — |
| 6Q8J | Nterminal domain of human SMU1 in complex with LSP641 | x-ray diffraction | A | XS4 | — |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 4Z | — | 1 (best 0.77) |
| 8H6L | Cryo-EM structure of human exon-defined spliceosome in the early B state. | electron microscopy | 4Z | — | 1 (best 0.77) |
| 8QO9 | Cryo-EM structure of a human spliceosomal B complex protomer | electron microscopy | v, w | — | 2 (best 0.81) |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | w, v | — | — |
| Q2TAY7 | AlphaFold monomer V2.0 prediction for WD40 repeat-containing protein SMU1 (Q2TAY7) | predicted | A | — | 2 (best 0.80) |
Ligands
Experiment against prediction
- 6Q8J chain A against the predicted model Q2TAY7: TM-score 0.91, RMSD 2.07 Å
- 6Q8J chain A against the predicted model Q2TAY7: TM-score 0.91, RMSD 2.07 Å
- 6Q8I chain A against the predicted model Q2TAY7: TM-score 0.78, RMSD 3.00 Å
- 6Q8I chain A against the predicted model Q2TAY7: TM-score 0.78, RMSD 3.00 Å
- 6Q8I chain E against the predicted model Q2TAY7: TM-score 0.78, RMSD 3.07 Å
- 6Q8I chain E against the predicted model Q2TAY7: TM-score 0.78, RMSD 3.07 Å
- 6Q8I chain J against the predicted model Q2TAY7: TM-score 0.76, RMSD 3.30 Å
- 6Q8I chain J against the predicted model Q2TAY7: TM-score 0.76, RMSD 3.30 Å
- 6Q8I chain B against the predicted model Q2TAY7: TM-score 0.76, RMSD 3.08 Å
- 6Q8I chain B against the predicted model Q2TAY7: TM-score 0.76, RMSD 3.08 Å
Elsewhere
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