UniProt Q15393
Splicing factor 3B subunit 3 (Q15393)
Splicing factor 3B subunit 3 (UniProt Q15393): 41 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 83 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15393
- Protein
- Splicing factor 3B subunit 3
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 83 · 11 records with a druggable one
Structures
42 records of Q15393 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IFE | Crystal structure of the human SF3b core complex | x-ray diffraction | A | K | — |
| 5IFE | Crystal structure of the human SF3B core complex | x-ray diffraction | A | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | w | — | — |
| 5O9Z | Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) | electron microscopy | w | — | — |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | 3 | — | — |
| 5ZYA | SF3B spliceosomal complex bound to E7107 | electron microscopy | A | K | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | 3 | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | 3 | — | — |
| 6EN4 | SF3B core in complex with a splicing modulator | x-ray diffraction | A | — | — |
| 6FF4 | human Bact spliceosome core structure | electron microscopy | v | — | 6 (best 0.84) |
| 6FF4 | Human bact spliceosome core structure | electron microscopy | v | — | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | v | — | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | B3 | — | 5 (best 0.86) |
| 6Y50 | 5'domain of human 17S U2 snRNP | electron microscopy | v | — | 16 (best 0.85) |
| 6Y50 | 5'DOMAIN of human 17S U2 snrnp | electron microscopy | v | — | — |
| 6Y5Q | Human 17S U2 snrnp | electron microscopy | v | — | — |
| 7ABH | Human pre-bact-2 spliceosome (SF3B/U2 snrnp portion) | electron microscopy | E | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | E | — | — |
| 7B0I | Structure of a minimal SF3B core in complex with spliceostatin A (form II) | x-ray diffraction | A | — | — |
| 7B0I | Structure of a minimal SF3B core in complex with spliceostatin a (form II) | x-ray diffraction | A | — | — |
| 7B91 | Structure of a minimal SF3B core in complex with pladienolide D (form I) | x-ray diffraction | A | — | — |
| 7B92 | Structure of a minimal SF3B core in complex with sudemycin D6 (form II) | x-ray diffraction | A | — | — |
| 7B9C | Structure of a minimal SF3B core in complex with spliceostatin a (form I) | x-ray diffraction | A | — | — |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | 3 | — | — |
| 7EVN | The cryo-EM structure of the DDX42-SF3b complex | electron microscopy | A | — | — |
| 7EVN | The cryo-EM structure of the DDX42-SF3B complex | electron microscopy | A | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snRNP | electron microscopy | 3 | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snrnp | electron microscopy | 3 | — | — |
| 7KTS | Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing module) | electron microscopy | S | — | 4 (best 0.84) |
| 7OMF | Structure of a minimal SF3B core in complex with sudemycin D6 (form I) | x-ray diffraction | A | — | — |
| 7ONB | Structure of the U2 5' module of the A3'-ssa complex | electron microscopy | A | — | — |
| 7OPI | Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E (form I) | x-ray diffraction | A | — | — |
| 7Q3L | Human 17S U2 snrnp 5' domain | electron microscopy | C | — | — |
| 7Q4O | Substrate-bound a-like U2 snrnp | electron microscopy | C | — | — |
| 7Q4P | U2 snRNP after ATP-dependent remodelling | electron microscopy | C | — | 14 (best 0.85) |
| 7Q4P | U2 snrnp after ATP-dependent remodelling | electron microscopy | C | — | — |
| 7VPX | The cryo-EM structure of the human pre-A complex | electron microscopy | 3 | — | 8 (best 0.84) |
| 8HK1 | The cryo-EM structure of human pre-17S U2 snRNP | electron microscopy | 3 | — | 10 (best 0.84) |
| 8I0U | The cryo-EM structure of human Bact-IV complex | electron microscopy | 3 | — | 3 (best 0.86) |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | B3 | — | 3 (best 0.85) |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | B3 | — | 2 (best 0.85) |
| Q15393 | AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q15393) | predicted | A | — | 12 (best 0.87) |
Ligands
- K · Potassium ion · in 2 records
Experiment against prediction
- 7Q4P chain C against the predicted model Q15393: TM-score 0.99, RMSD 0.85 Å
- 7Q4P chain C against the predicted model Q15393: TM-score 0.99, RMSD 0.85 Å
- 7ABI chain E against the predicted model Q15393: TM-score 0.99, RMSD 0.97 Å
- 7B91 chain A against the predicted model Q15393: TM-score 0.99, RMSD 0.80 Å
- 7B92 chain A against the predicted model Q15393: TM-score 0.99, RMSD 0.75 Å
- 7B0I chain A against the predicted model Q15393: TM-score 0.99, RMSD 0.75 Å
- 7B0I chain A against the predicted model Q15393: TM-score 0.99, RMSD 0.75 Å
- 7ABH chain E against the predicted model Q15393: TM-score 0.99, RMSD 1.02 Å
- 7OPI chain A against the predicted model Q15393: TM-score 0.99, RMSD 0.79 Å
- 7OPI chain A against the predicted model Q921M3: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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