UniProt Q86U44
N6-adenosine-methyltransferase catalytic subunit (Q86U44)
N6-adenosine-methyltransferase catalytic subunit (UniProt Q86U44), EC 2.1.1.348, 2.1.1.62: 108 experimental structures on GenesisL1, 53 ligands bound, 105 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q86U44
- Protein
- N6-adenosine-methyltransferase catalytic subunit
- EC
- 2.1.1.348, 2.1.1.62
- Experimental structures
- 108
- Predicted models
- 0
- Ligands
- 53
- Pockets
- 105 · 38 records with a druggable one
Structures
108 records of Q86U44 in the MolNFT archive: 108 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IL0 | Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation | x-ray diffraction | A | — | 6 (best 0.63) |
| 5IL0 | Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation | x-ray diffraction | A | — | — |
| 5IL1 | Crystal structure of SAM-bound METTL3-METTL14 complex | x-ray diffraction | A | — | — |
| 5IL1 | Crystal structure of SAM-bound METTL3-METTL14 complex | x-ray diffraction | A | — | — |
| 5IL2 | Crystal structure of SAH-bound METTL3-METTL14 complex | x-ray diffraction | A | — | — |
| 5IL2 | Crystal structure of sah-bound METTL3-METTL14 complex | x-ray diffraction | A | — | — |
| 5K7M | Crystal structure of the catalytic domains of Mettl3/Mettl14 complex | x-ray diffraction | A | — | — |
| 5K7M | Crystal structure of the catalytic domains of METTL3/METTL14 complex | x-ray diffraction | A | — | — |
| 5K7U | Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM | x-ray diffraction | A | SAM | 4 (best 0.68) |
| 5K7U | Crystal structure of the catalytic domains of METTL3/METTL14 complex with SAM | x-ray diffraction | A | — | — |
| 5K7W | Crystal structure of the catalytic domain of Mettl3/Mettl14 complex with SAH | x-ray diffraction | A | — | — |
| 5K7W | Crystal structure of the catalytic domain of METTL3/METTL14 complex with sah | x-ray diffraction | A | — | — |
| 5L6D | Crystal structure of the human METTL3-METTL14 complex bound to SAH | x-ray diffraction | A | MG | — |
| 5L6D | Crystal structure of the human METTL3-METTL14 complex bound to sah | x-ray diffraction | A | MG | — |
| 5L6E | Crystal structure of the human METTL3-METTL14 complex bound to SAM | x-ray diffraction | A | MG | — |
| 5L6E | Crystal structure of the human METTL3-METTL14 complex bound to SAM | x-ray diffraction | A | MG | — |
| 5TEY | Human METTL3-METTL14 complex | x-ray diffraction | A | SAH, MG, UNX | 3 (best 0.63) |
| 5TEY | Human METTL3-METTL14 complex | x-ray diffraction | A | MG, UNX | — |
| 5YZ9 | Zinc finger domain of METTL3-METTL14 N6-methyladenosine methyltransferase | solution nmr; solution scattering | A | ZN | — |
| 6TTP | Crystal structure of the human METTL3-METTL14 complex bound to Compound 1/Adenosine (DHU_M3M_023) | x-ray diffraction | A | ADN | — |
| 6TTP | Crystal structure of the human METTL3-METTL14 complex bound to compound 1/ADENOSINE (DHU_M3M_023) | x-ray diffraction | A | ADN | — |
| 6TTT | Crystal structure of the human METTL3-METTL14 complex bound to Compound 2 (ASI_M3M_140) | x-ray diffraction | A | NWQ | 3 (best 0.59) |
| 6TTT | Crystal structure of the human METTL3-METTL14 complex bound to compound 2 (ASI_M3M_140) | x-ray diffraction | A | NWQ | — |
| 6TTV | Crystal structure of the human METTL3-METTL14 complex bound to Compound 3 (ASI_M3M_138) | x-ray diffraction | A | NWW | 2 (best 0.51) |
| 6TTV | Crystal structure of the human METTL3-METTL14 complex bound to compound 3 (ASI_M3M_138) | x-ray diffraction | A | NWW | — |
| 6TTW | Crystal structure of the human METTL3-METTL14 complex bound to compound 4 (ASI_M3M_047) | x-ray diffraction | A | NWZ | — |
| 6TTX | Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051) | x-ray diffraction | A | NX8 | 1 (best 0.50) |
| 6TTX | Crystal structure of the human METTL3-METTL14 complex bound to compound 5 (ASI_M3M_051) | x-ray diffraction | A | NX8 | — |
| 6TU1 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ASI_M3M_091) | x-ray diffraction | A | NXB | — |
| 6TU1 | Crystal structure of the human METTL3-METTL14 complex bound to compound 8 (ASI_M3M_091) | x-ray diffraction | A | NXB | — |
| 6Y4G | Crystal structure of the human METTL3-METTL14 complex bound to sinefungin | x-ray diffraction | A | — | — |
| 7ACD | Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1a) | x-ray diffraction | A | R72 | 4 (best 0.59) |
| 7ACD | Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1A) | x-ray diffraction | A | R72 | — |
| 7NHG | Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041 | x-ray diffraction | A | UDQ | — |
| 7NHG | Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041 | x-ray diffraction | A | UDQ | — |
| 7NHH | Crystal structure of the human METTL3-METTL14 complex with compound UOZ002 | x-ray diffraction | A | MG, UDK | — |
| 7NHI | Crystal structure of the human METTL3-METTL14 complex with compound UOZ004 | x-ray diffraction | A | UE2 | 2 (best 0.58) |
| 7NHI | Crystal structure of the human METTL3-METTL14 complex with compound UOZ004 | x-ray diffraction | A | UE2 | — |
| 7NHJ | Crystal structure of the human METTL3-METTL14 complex with compound DHU_M3M_154 | x-ray diffraction | A | UDW | — |
| 7NHV | Crystal structure of the human METTL3-METTL14 complex with compound UOZ016 | x-ray diffraction | A | UE5 | — |
| 7NI7 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ031 | x-ray diffraction | A | UEH | — |
| 7NI8 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ040a | x-ray diffraction | A | UEE | 2 (best 0.56) |
| 7NI8 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ040A | x-ray diffraction | A | UEE | — |
| 7NI9 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ058 | x-ray diffraction | A | UEW | 3 (best 0.55) |
| 7NI9 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ058 | x-ray diffraction | A | UEW | — |
| 7NIA | Crystal structure of the human METTL3-METTL14 complex with compound UOZ059a | x-ray diffraction | A | UEQ | 2 (best 0.62) |
| 7NIA | Crystal structure of the human METTL3-METTL14 complex with compound UOZ059A | x-ray diffraction | A | UEQ | — |
| 7NID | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | x-ray diffraction | A | UEZ | 3 (best 0.57) |
| 7NID | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | x-ray diffraction | A | UEZ | — |
| 7O08 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075) | x-ray diffraction | A | UXE | 3 (best 0.63) |
| 7O08 | Crystal structure of the human METTL3-METTL14 complex bound to compound 5 (ADO_AB_075) | x-ray diffraction | A | UXE | — |
| 7O09 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074) | x-ray diffraction | A | UXK | 1 (best 0.57) |
| 7O09 | Crystal structure of the human METTL3-METTL14 complex bound to compound 7 (ADO_AC_074) | x-ray diffraction | A | UXK | — |
| 7O0L | Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093) | x-ray diffraction | A | UXW | 3 (best 0.66) |
| 7O0L | Crystal structure of the human METTL3-METTL14 complex bound to compound 8 (ADO_AC_093) | x-ray diffraction | A | UXW | — |
| 7O0M | Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023) | x-ray diffraction | A | UXT | 2 (best 0.64) |
| 7O0M | Crystal structure of the human METTL3-METTL14 complex bound to compound 9 (ADO_AD_023) | x-ray diffraction | A | UXT | — |
| 7O0P | Crystal structure of the human METTL3-METTL14 complex bound to compound 10 (ADO_AD_022) | x-ray diffraction | A | UXZ | — |
| 7O0Q | Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066) | x-ray diffraction | A | UY2 | 3 (best 0.63) |
| 7O0Q | Crystal structure of the human METTL3-METTL14 complex bound to compound 12 (ADO_AD_066) | x-ray diffraction | A | UY2 | — |
48 records more on the page itself.
Ligands
- MG · Magnesium ion · in 9 records
- UEE · (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl) methyl)benzamide · in 4 records
- 0AE · (3~{R})-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-3-[[[6-[[(3~{S})-3-propan-2-yl-2-azoniaspiro[3.3]heptan-2-yl]methyl]naphthalen-1-yl]amino]methyl]piperidin-3-ol · in 2 records
- 0BA · 2-oxidanyl-N-[[(3R)-3-oxidanyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methyl]-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide · in 2 records
- 0BH · N-[[(3R)-1-[6-(1-benzothiophen-4-ylmethylamino) pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide · in 2 records
- 6IK · 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3S)-3-oxidanyl-1-[6-[(phenylmethyl) amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide · in 2 records
- ADN · Adenosine · in 2 records
- NWQ · (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide · in 2 records
- NWW · (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolane-2-carboxamide · in 2 records
- NX8 · (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-(piperidin-4-ylmethyl)oxolane-2-carboxamide · in 2 records
- NXB · (2~{R},3~{R},4~{R},5~{R})-2-[(6-aminopurin-9-yl) methyl]-5-azanyl-oxane-3,4-diol · in 2 records
- R72 · 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl) amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide · in 2 records
- UDQ · N-[[(3R)-3-hydroxy-1-[6-(methylamino)pyrimidin-4-yl]piperidin-3-yl]methyl]-4-(piperidin-1-ylmethyl) benzamide · in 2 records
- UE2 · (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl) piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl) methyl)benzamide · in 2 records
- UEQ · 4-[[(3R)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl) amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide · in 2 records
- UEW · N-(((R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-(((S)-1-isopropyl-2-azaspiro[3.3]heptan-2-yl)methyl)benzamide · in 2 records
- UEZ · (R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((4,4-dimethylpiperidin-1-yl)methyl)naphthalen-1-yl)amino) methyl)piperidin-3-ol · in 2 records
- UNX · Unknown atom or ion · in 2 records
- UXE · 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol · in 2 records
- UXK · 6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-N-(phenylmethyl)pyrimidin-4-amine · in 2 records
- UXT · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UXW · 4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UY2 · 3-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-8-[6-(methylamino)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-2-one · in 2 records
- UY5 · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UYZ · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UZ5 · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UZB · 9-(2-chloranyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UZE · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-fluoranyl-phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- UZH · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-3-fluoranyl-phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · in 2 records
- V22 · ~{N}-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxidanylidene-1~{H}-pyrido[1, 2-a]pyrimidine-2-carboxamide · in 2 records
Elsewhere
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