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Ligand · UZ5

UZ5 · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one

UZ5, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one (C27 H37 F2 N7 O, 513.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
UZ5
Formula
C27 H37 F2 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

UZ5 in 2 structures; the first of them:

  • 7O2F · Crystal structure of the human METTL3-METTL14 complex bound to Compound 22 (UZH2) · UZ5 A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 14 more
  • 7O2F · Crystal structure of the human METTL3-METTL14 complex bound to compound 22 (UZH2) · UZ5 A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 10 more

Residues it binds most

ARG 2, ASP 2, GLY 2, PRO 2, TRP 2, ASN 2, CYS 2, GLU 2, ILE 2, LEU 2 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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