MolNFT v1 · #183182 · protein

Crystal structure of the human METTL3-METTL14 complex with compound UOZ002

7NHH: “Crystal structure of the human METTL3-METTL14 complex with compound UOZ002”. X-ray diffraction, 2 ligands (UDK, MG). MolNFT v1 #183182 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NHH
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q86U44, Q9HCE5
Ligands: UDK, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	198	—	Q86U44
B	—	protein	236	—	Q9HCE5

Ligands and binding sites

UDK · (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl) piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl) methyl)benzamide · ligand · chains A
MG · Magnesium ion · metal · 4 copies · chains A, B
ACT · Acetate ion · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7NHH · Crystal structure of the human METTL3-METTL14 complex with compound UOZ002 · the same entry in another collection · chain A against A, TM-score 1.00
Q86U44 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Q9HCE5 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase non-catalytic… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86U44
Every structure of UniProt Q9HCE5
Elsewhere: RCSB PDB 7NHH · PDBe 7NHH · UniProt Q86U44 · UniProt Q9HCE5

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