UniProt Q9HCE5
N6-adenosine-methyltransferase non-catalytic subunit (Q9HCE5)
N6-adenosine-methyltransferase non-catalytic subunit (UniProt Q9HCE5), EC 2.1.1.62: 83 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 49 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9HCE5
- Protein
- N6-adenosine-methyltransferase non-catalytic subunit
- EC
- 2.1.1.62
- Experimental structures
- 83
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 49 · 16 records with a druggable one
Structures
84 records of Q9HCE5 in the MolNFT archive: 83 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IL0 | Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation | x-ray diffraction | B | — | — |
| 5IL1 | Crystal structure of SAM-bound METTL3-METTL14 complex | x-ray diffraction | B | — | — |
| 5IL1 | Crystal structure of SAM-bound METTL3-METTL14 complex | x-ray diffraction | B | — | — |
| 5IL2 | Crystal structure of SAH-bound METTL3-METTL14 complex | x-ray diffraction | B | — | — |
| 5IL2 | Crystal structure of sah-bound METTL3-METTL14 complex | x-ray diffraction | B | — | — |
| 5K7M | Crystal structure of the catalytic domains of Mettl3/Mettl14 complex | x-ray diffraction | B | — | — |
| 5K7M | Crystal structure of the catalytic domains of METTL3/METTL14 complex | x-ray diffraction | B | — | — |
| 5K7U | Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM | x-ray diffraction | B | — | 5 (best 0.68) |
| 5K7U | Crystal structure of the catalytic domains of METTL3/METTL14 complex with SAM | x-ray diffraction | B | — | — |
| 5K7W | Crystal structure of the catalytic domain of Mettl3/Mettl14 complex with SAH | x-ray diffraction | B | — | — |
| 5K7W | Crystal structure of the catalytic domain of METTL3/METTL14 complex with sah | x-ray diffraction | B | — | — |
| 5L6D | Crystal structure of the human METTL3-METTL14 complex bound to SAH | x-ray diffraction | B | — | — |
| 5L6D | Crystal structure of the human METTL3-METTL14 complex bound to sah | x-ray diffraction | B | — | — |
| 5L6E | Crystal structure of the human METTL3-METTL14 complex bound to SAM | x-ray diffraction | B | — | — |
| 5L6E | Crystal structure of the human METTL3-METTL14 complex bound to SAM | x-ray diffraction | B | — | — |
| 5TEY | Human METTL3-METTL14 complex | x-ray diffraction | B | MG, UNX | 3 (best 0.63) |
| 5TEY | Human METTL3-METTL14 complex | x-ray diffraction | B | MG, UNX | — |
| 6TTP | Crystal structure of the human METTL3-METTL14 complex bound to Compound 1/Adenosine (DHU_M3M_023) | x-ray diffraction | B | — | — |
| 6TTP | Crystal structure of the human METTL3-METTL14 complex bound to compound 1/ADENOSINE (DHU_M3M_023) | x-ray diffraction | B | — | — |
| 6TTT | Crystal structure of the human METTL3-METTL14 complex bound to compound 2 (ASI_M3M_140) | x-ray diffraction | B | — | — |
| 6TTV | Crystal structure of the human METTL3-METTL14 complex bound to compound 3 (ASI_M3M_138) | x-ray diffraction | B | — | — |
| 6TTW | Crystal structure of the human METTL3-METTL14 complex bound to compound 4 (ASI_M3M_047) | x-ray diffraction | B | — | — |
| 6TTX | Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051) | x-ray diffraction | B | — | 2 (best 0.54) |
| 6TTX | Crystal structure of the human METTL3-METTL14 complex bound to compound 5 (ASI_M3M_051) | x-ray diffraction | B | — | — |
| 6TU1 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ASI_M3M_091) | x-ray diffraction | B | — | — |
| 6TU1 | Crystal structure of the human METTL3-METTL14 complex bound to compound 8 (ASI_M3M_091) | x-ray diffraction | B | — | — |
| 6Y4G | Crystal structure of the human METTL3-METTL14 complex bound to sinefungin | x-ray diffraction | B | — | — |
| 7ACD | Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1A) | x-ray diffraction | B | MG | — |
| 7NHG | Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041 | x-ray diffraction | B | — | — |
| 7NHG | Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041 | x-ray diffraction | B | — | — |
| 7NHH | Crystal structure of the human METTL3-METTL14 complex with compound UOZ002 | x-ray diffraction | B | MG | — |
| 7NHI | Crystal structure of the human METTL3-METTL14 complex with compound UOZ004 | x-ray diffraction | B | — | — |
| 7NHJ | Crystal structure of the human METTL3-METTL14 complex with compound DHU_M3M_154 | x-ray diffraction | B | — | — |
| 7NHV | Crystal structure of the human METTL3-METTL14 complex with compound UOZ016 | x-ray diffraction | B | — | — |
| 7NI7 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ031 | x-ray diffraction | B | MG | — |
| 7NI8 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ040a | x-ray diffraction | B | — | 3 (best 0.62) |
| 7NI8 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ040A | x-ray diffraction | B | — | — |
| 7NI9 | Crystal structure of the human METTL3-METTL14 complex with compound UOZ058 | x-ray diffraction | B | — | — |
| 7NIA | Crystal structure of the human METTL3-METTL14 complex with compound UOZ059a | x-ray diffraction | B | — | 2 (best 0.62) |
| 7NIA | Crystal structure of the human METTL3-METTL14 complex with compound UOZ059A | x-ray diffraction | B | — | — |
| 7NID | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | x-ray diffraction | B | — | — |
| 7O08 | Crystal structure of the human METTL3-METTL14 complex bound to compound 5 (ADO_AB_075) | x-ray diffraction | B | — | — |
| 7O09 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074) | x-ray diffraction | B | — | 2 (best 0.53) |
| 7O09 | Crystal structure of the human METTL3-METTL14 complex bound to compound 7 (ADO_AC_074) | x-ray diffraction | B | — | — |
| 7O0L | Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093) | x-ray diffraction | B | — | 3 (best 0.66) |
| 7O0L | Crystal structure of the human METTL3-METTL14 complex bound to compound 8 (ADO_AC_093) | x-ray diffraction | B | — | — |
| 7O0M | Crystal structure of the human METTL3-METTL14 complex bound to compound 9 (ADO_AD_023) | x-ray diffraction | B | — | — |
| 7O0P | Crystal structure of the human METTL3-METTL14 complex bound to compound 10 (ADO_AD_022) | x-ray diffraction | B | — | — |
| 7O0Q | Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066) | x-ray diffraction | B | MG | 2 (best 0.63) |
| 7O0Q | Crystal structure of the human METTL3-METTL14 complex bound to compound 12 (ADO_AD_066) | x-ray diffraction | B | MG | — |
| 7O0R | Crystal structure of the human METTL3-METTL14 complex bound to Compound 15 (ADO_AE_026) | x-ray diffraction | B | — | — |
| 7O0R | Crystal structure of the human METTL3-METTL14 complex bound to compound 15 (ADO_AE_026) | x-ray diffraction | B | — | — |
| 7O27 | Crystal structure of the human METTL3-METTL14 complex bound to compound 17 (ADO_AE_005) | x-ray diffraction | B | — | — |
| 7O28 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 19 (ADO_AE_009) | x-ray diffraction | B | — | — |
| 7O28 | Crystal structure of the human METTL3-METTL14 complex bound to compound 19 (ADO_AE_009) | x-ray diffraction | B | — | — |
| 7O29 | Crystal structure of the human METTL3-METTL14 complex bound to compound 20 (ADO_AD_044) | x-ray diffraction | B | — | — |
| 7O2E | Crystal structure of the human METTL3-METTL14 complex bound to compound 21 (ADO_AD_089) | x-ray diffraction | B | — | — |
| 7O2F | Crystal structure of the human METTL3-METTL14 complex bound to compound 22 (UZH2) | x-ray diffraction | B | — | — |
| 7O2H | Crystal structure of the human METTL3-METTL14 complex bound to compound 13 (ADO_AD_091) | x-ray diffraction | B | — | — |
| 7O2I | METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457 | x-ray diffraction | B | — | — |
24 records more on the page itself.
Ligands
Experiment against prediction
- 5K7M chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.21 Å
- 5K7M chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.21 Å
- 5K7W chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.23 Å
- 5K7W chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.23 Å
- 5K7U chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.25 Å
- 5K7U chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.25 Å
- 7RX8 chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.25 Å
- 5IL1 chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.36 Å
- 5IL1 chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.36 Å
- 5IL2 chain B against the predicted model Q9HCE5: TM-score 1.00, RMSD 0.39 Å
Elsewhere
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