Crystal structure of the human METTL3-METTL14 complex bound to compound 21 (ADO_AD_089)

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• UZH · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-3-fluoranyl-phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one · ligand · chains A
• ACT · Acetate ion · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7O2E · Crystal structure of the human METTL3-METTL14 complex bound to Compound 21 (ADO_AD_089) · the same entry in another collection · chain A against A, TM-score 1.00
• Q86U44 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q9HCE5 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase non-catalytic… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q86U44
• Every structure of UniProt Q9HCE5
• Elsewhere: RCSB PDB 7O2E · PDBe 7O2E · UniProt Q86U44 · UniProt Q9HCE5