Crystal structure of the human METTL3-METTL14 complex with compound UOZ040A

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• UEE · (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl) methyl)benzamide · ligand · chains A
• ACT · Acetate ion · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7NI8 · Crystal structure of the human METTL3-METTL14 complex with compound UOZ040a · the same entry in another collection · chain A against A, TM-score 1.00
• Q86U44 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q9HCE5 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase non-catalytic… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q86U44
• Every structure of UniProt Q9HCE5
• Elsewhere: RCSB PDB 7NI8 · PDBe 7NI8 · UniProt Q86U44 · UniProt Q9HCE5