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Ligand · UEE

UEE · (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl) methyl)benzamide

UEE, (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl) methyl)benzamide (C31 H38 N6 O2, 526.7 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every…

Component
UEE
Formula
C31 H38 N6 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

UEE in 4 structures; the first of them:

  • 7NI8 · Crystal structure of the human METTL3-METTL14 complex with compound UOZ040a · UEE A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 15 more
  • 7OEG · Crystal structure of the human METTL3-METTL14 complex with compound UOZ040b · UEE A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 15 more
  • 7NI8 · Crystal structure of the human METTL3-METTL14 complex with compound UOZ040A · UEE A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, GLY407, THR408 and 11 more
  • 7OEG · Crystal structure of the human METTL3-METTL14 complex with compound UOZ040B · UEE A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 14 more

Residues it binds most

GLY 4, ARG 4, ASP 4, TRP 4, PRO 4, ASN 4, CYS 4, GLN 4, GLU 4, ILE 4 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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