MolNFT v1 · #125348 · protein

Crystal structure of the human METTL3-METTL14 complex bound to SAM

5L6E: “Crystal structure of the human METTL3-METTL14 complex bound to SAM”. X-ray diffraction, 1 ligand (MG). MolNFT v1 #125348 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5L6E
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q86U44, Q9HCE5
Ligands: MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	200	—	Q86U44
B	—	protein	236	—	Q9HCE5

Ligands and binding sites

MG · Magnesium ion · metal · chains A
ACT · Acetate ion · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5L6E · Crystal structure of the human METTL3-METTL14 complex bound to SAM · the same entry in another collection · chain B against B, TM-score 1.00
Q86U44 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
Q9HCE5 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase non-catalytic… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86U44
Every structure of UniProt Q9HCE5
Elsewhere: RCSB PDB 5L6E · PDBe 5L6E · UniProt Q86U44 · UniProt Q9HCE5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.