GL1X · GenesisL1 explorer

Ligand · UYZ

UYZ · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one

UYZ, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one (C28 H37 N7 O, 487.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
UYZ
Formula
C28 H37 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

UYZ in 2 structures; the first of them:

  • 7O27 · Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005) · UYZ A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 12 more
  • 7O27 · Crystal structure of the human METTL3-METTL14 complex bound to compound 17 (ADO_AE_005) · UYZ A601 · binds CYS376, ASP377, ILE378, ASP395, PRO396, PRO397, TYR406, GLY407 and 10 more

Residues it binds most

GLY 2, ASP 2, PRO 2, ARG 2, TRP 2, ASN 2, CYS 2, GLU 2, ILE 2, LEU 2 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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