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Ligand · UXZ

UXZ · 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one

UXZ, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one (C27 H39 N7 O, 477.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
UXZ
Formula
C27 H39 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

UXZ in 2 structures; the first of them:

  • 7O0P · Crystal structure of the human METTL3-METTL14 complex bound to Compound 10 (ADO_AD_022) · UXZ A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, TYR406 and 14 more
  • 7O0P · Crystal structure of the human METTL3-METTL14 complex bound to compound 10 (ADO_AD_022) · UXZ A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, TYR406, LEU409 and 11 more

Residues it binds most

GLY 2, ARG 2, ASP 2, PRO 2, TRP 2, ASN 2, CYS 2, GLN 2, GLU 2, HIS 2 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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