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Ligand · UXE

UXE · 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol

UXE, 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol (C30 H41 N7 O, 515.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
UXE
Formula
C30 H41 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

UXE in 2 structures; the first of them:

  • 7O08 · Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075) · UXE A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, GLY407 and 14 more
  • 7O08 · Crystal structure of the human METTL3-METTL14 complex bound to compound 5 (ADO_AB_075) · UXE A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, GLY407 and 11 more

Residues it binds most

GLY 2, ASP 2, PRO 2, ARG 2, TRP 2, ASN 2, CYS 2, GLN 2, GLU 2, ILE 2 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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