UniProt O35433
Transient receptor potential cation channel subfamily V member 1 (O35433)
Transient receptor potential cation channel subfamily V member 1 (UniProt O35433): 68 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 147 pockets. Binding sites, druggability and experiment against…
- UniProt
- O35433
- Protein
- Transient receptor potential cation channel subfamily V member 1
- Experimental structures
- 68
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 147 · 8 records with a druggable one
Structures
69 records of O35433 in the MolNFT archive: 68 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NYJ | Crystal structure of the ankyrin repeat domain of TRPV1 | x-ray diffraction | A | — | — |
| 2NYJ | Crystal structure of the ankyrin repeat domain of TRPV1 | x-ray diffraction | A | — | — |
| 2PNN | Crystal Structure of the Ankyrin Repeat Domain of Trpv1 | x-ray diffraction | A | — | — |
| 2PNN | Crystal structure of the ankyrin repeat domain of TRPV1 | x-ray diffraction | A | — | — |
| 3J5P | Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy | electron microscopy | B, A, C, D | — | — |
| 3J5P | Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy | electron microscopy | B, A, C, D | — | — |
| 3J5Q | Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron… | electron microscopy | D, B, E, G | — | — |
| 3J5Q | Structure of TRPV1 ion channel in complex with dktx and rtx determined by single particle electron… | electron microscopy | D, B, E, G | — | — |
| 3J5R | Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy | electron microscopy | B, A, C, D | — | — |
| 3J5R | Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy | electron microscopy | B, A, C, D | — | — |
| 3J9J | Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy | electron microscopy | A, B, C, D | — | — |
| 3J9J | Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy | electron microscopy | A, B, C, D | — | — |
| 3SUI | Crystal structure of ca2+-calmodulin in complex with a trpv1 c-terminal peptide | x-ray diffraction | B | — | — |
| 3SUI | Crystal structure of CA2+-calmodulin in complex with a TRPV1 C- terminal peptide | x-ray diffraction | B | — | — |
| 5IRX | Structure of TRPV1 in complex with dktx and rtx, determined in lipid nanodisc | electron microscopy | A, B, C, D | — | — |
| 5IRZ | Structure of TRPV1 determined in lipid nanodisc | electron microscopy | D, E, B, C | — | — |
| 5IS0 | Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc | electron microscopy | C, B, D, E | — | — |
| 7L2H | Cryo-EM structure of unliganded full-length TRPV1 at neutral pH | electron microscopy | A, D, B, C | XJ7, XJD, NA | — |
| 7L2I | Cryo-EM structure of full-length TRPV1 at PH6A state | electron microscopy | A, C, D, B | XJA | — |
| 7L2J | Cryo-EM structure of full-length TRPV1 at PH6C state | electron microscopy | A, B, C, D | XJ7 | — |
| 7L2K | Cryo-EM structure of full-length TRPV1 at PH6B state | electron microscopy | A, C, D, B | — | — |
| 7L2L | Cryo-EM structure of RTX-bound full-length TRPV1 in O1 state | electron microscopy | A, C, D, B | 6EU | 20 (best 0.85) |
| 7L2L | Cryo-EM structure of rtx-bound full-length TRPV1 in O1 state | electron microscopy | A, C, D, B | 6EU | — |
| 7L2M | Cryo-EM structure of DKTX/RTX-bound full-length TRPV1 | electron microscopy | A, C, D, B | 6EU | — |
| 7L2N | Cryo-EM structure of rtx-bound full-length TRPV1 in C1 state | electron microscopy | A, C, D, B | 6EU | — |
| 7L2O | Cryo-EM structure of RTX-bound full-length TRPV1 at pH 5.5 | electron microscopy | A, C, D, B | 6EU | 20 (best 0.85) |
| 7L2O | Cryo-EM structure of rtx-bound full-length TRPV1 at pH 5.5 | electron microscopy | A, C, D, B | 6EU | — |
| 7L2P | Cryo-EM structure of unliganded minimal TRPV1 | electron microscopy | A, D, B, C | XJ7, 6IY, NA | — |
| 7L2R | Cryo-EM structure of dktx-bound minimal TRPV1 at the pre-open state | electron microscopy | A, B, C, D | XJ7, 65I, NA | — |
| 7L2S | cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state | electron microscopy | D, A, B, C | XJ7, 6IY, NA | — |
| 7L2S | Cryo-EM structure of dktx-bound minimal TRPV1 at the pre-bound state | electron microscopy | D, A, B, C | XJ7, 6IY, NA | — |
| 7L2T | Cryo-EM structure of dktx-bound minimal TRPV1 in partial open state | electron microscopy | A, B, C, D | XJ7, NA, 65I | — |
| 7L2U | Cryo-EM structure of dktx-bound minimal TRPV1 in open state | electron microscopy | A, B, C, D | XJ7, XKP, NA | — |
| 7L2V | Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state B | electron microscopy | A, D, B, C | 6EU, XPS, NA | — |
| 7L2W | Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state a | electron microscopy | A, D, B, C | 6EU, 6IY, NA | — |
| 7L2X | cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state c | electron microscopy | A, D, B, C | 6EU, 6IY, XPJ | 20 (best 0.82) |
| 7L2X | Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state C | electron microscopy | A, D, B, C | 6EU, 6IY, XPJ | — |
| 7LP9 | Cryo-EM structure of full-length TRPV1 at 4 degrees celsius | electron microscopy | A, B, C, D | T7X, LBN, 6OU, NA, YFP | — |
| 7LPA | Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | electron microscopy | A, B, C, D | LBN, 6OU, 4DY, YFP, NA | — |
| 7LPA | Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees celsius | electron microscopy | A, B, C, D | LBN, 6OU, 4DY, YFP, NA | — |
| 7LPB | Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees celsius | electron microscopy | A, B, C, D | LBN, 6OU, YFP, 4DY | — |
| 7LPC | Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | electron microscopy | C, A, B, D | 6OU, LBN, YFP, T7X | — |
| 7LPC | Cryo-EM structure of full-length TRPV1 at 48 degrees celsius | electron microscopy | C, A, B, D | 6OU, LBN, YFP, T7X | — |
| 7LPD | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees celsius, in an intermediate… | electron microscopy | A, B, C, D | LBN, 6OU, 4DY | — |
| 7LPE | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees celsius, in an open state… | electron microscopy | C, B, A, D | LBN, 6OU, 4DY | — |
| 7MZ5 | Cryo-EM structure of RTX-bound full-length TRPV1 in C2 state | electron microscopy | A, C, D, B | 6EU, NA | 20 (best 0.89) |
| 7MZ5 | Cryo-EM structure of rtx-bound full-length TRPV1 in C2 state | electron microscopy | A, C, D, B | 6EU, NA | — |
| 7MZ6 | Cryo-EM structure of minimal TRPV1 with 1 perturbed pi | electron microscopy | A, D, B, C | XJ7, 6IY, NA | — |
| 7MZ7 | Cryo-EM structure of minimal TRPV1 with 4 partially bound RTX | electron microscopy | A, D, B, C | 6EU, NA | — |
| 7MZ7 | Cryo-EM structure of minimal TRPV1 with 4 partially bound rtx | electron microscopy | A, D, B, C | 6EU, NA | — |
| 7MZ9 | Cryo-EM structure of minimal TRPV1 with 1 partially bound RTX | electron microscopy | A, D, C, B | 6EU, XJ7, NA | — |
| 7MZ9 | Cryo-EM structure of minimal TRPV1 with 1 partially bound rtx | electron microscopy | A, D, C, B | 6EU, XJ7, NA | — |
| 7MZA | Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets | electron microscopy | A, D, B, C | XJ7, 6EU, NA | — |
| 7MZA | Cryo-EM structure of minimal TRPV1 with 2 bound rtx in adjacent pockets | electron microscopy | A, D, B, C | XJ7, 6EU, NA | — |
| 7MZB | Cryo-EM structure of minimal TRPV1 with 3 bound rtx and 1 perturbed pi | electron microscopy | A, D, B, C | XJ7, 6EU, NA | — |
| 7MZC | Cryo-EM structure of minimal TRPV1 with rtx bound in C1 state | electron microscopy | A, D, B, C | 6EU, NA | — |
| 7MZD | Cryo-EM structure of minimal TRPV1 with RTX bound in C2 state | electron microscopy | A, D, B, C | 6EU, NA | — |
| 7MZD | Cryo-EM structure of minimal TRPV1 with rtx bound in C2 state | electron microscopy | A, D, B, C | 6EU, NA | — |
| 7MZE | Cryo-EM structure of minimal TRPV1 with 2 bound rtx in opposite pockets | electron microscopy | A, D, B, C | XJ7, NA, 6EU | — |
| 7RQU | Cryo-EM structure of the full-length TRPV1 with rtx at 4 degrees celsius, in a closed state, class I | electron microscopy | A, C, B, D | 6EU, LBN, 6OU, YFP, NA | — |
9 records more on the page itself.
Ligands
- NA · Sodium ion · in 31 records
- 6EU · resiniferatoxin · in 30 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 15 records
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 15 records
- XJ7 · (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2r,3s,4s,5r, 6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate · in 15 records
- 6IY · (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate · in 7 records
- YFP · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol · in 7 records
- 4DY · (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide · in 5 records
- T7X · Phosphatidylinositol · in 3 records
- 65I · (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate · in 2 records
- XPJ · 1-deoxy-1-(methylamino)-D-allitol · in 2 records
- 8IJ · (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate · in 1 record
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 1 record
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 1 record
- XJA · (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1s,2r,3r,4r,5r, 6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate · in 1 record
- XJD · (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl tridecanoate · in 1 record
- XKP · (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate · in 1 record
- XPS · 6-deoxy-6-(methylamino)-D-galactitol · in 1 record
Experiment against prediction
- 2PNN chain A against the predicted model O35433: TM-score 0.98, RMSD 0.92 Å
- 2PNN chain A against the predicted model O35433: TM-score 0.98, RMSD 0.92 Å
- 2NYJ chain A against the predicted model O35433: TM-score 0.97, RMSD 1.03 Å
- 2NYJ chain A against the predicted model O35433: TM-score 0.97, RMSD 1.03 Å
- 3J5P chain B against the predicted model O35433: TM-score 0.97, RMSD 1.62 Å
- 3J5P chain B against the predicted model O35433: TM-score 0.97, RMSD 1.62 Å
- 7MZ9 chain D against the predicted model O35433: TM-score 0.97, RMSD 1.57 Å
- 7MZ9 chain D against the predicted model O35433: TM-score 0.97, RMSD 1.57 Å
- 7MZ9 chain C against the predicted model O35433: TM-score 0.97, RMSD 1.67 Å
- 7MZ9 chain C against the predicted model O35433: TM-score 0.97, RMSD 1.67 Å
Elsewhere
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