Ligand · NKN
NKN · (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate
NKN, (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate (C17 H35 O7 P, 382.4 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (9 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…
- Component
- NKN
- Formula
- C17 H35 O7 P
- Class
- ligand
- Structures
- 12
- PDB entries
- 9
Binding sites
NKN in 12 structures; the first of them:
- 3NKN · Crystal structure of mouse autotaxin in complex with 14:0-LPA · NKN A1006 · binds ILE167, SER169, ASP171, LYS208, THR209, PHE210, LEU213, LEU216 and 12 more
- 3QCU · Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic… · NKN H215 · binds LEU33, LEU50, ASN52, TYR56, PHE96, GLY97, TYR98, TYR99 and 13 more
- 3SAO · The Siderocalin Ex-FABP functions through dual ligand specificities · NKN A161 · binds VAL8, TRP12, ILE14, ILE38, LEU46, VAL48, TYR50, PHE65 and 10 more
- 8T0C · TRPV1 in Nanodisc bound with lysophosphatidic acid in all four monomers · NKN A901 · binds TYR511, SER512, LEU515, PHE522, PHE543, MET547, THR550, ASN551 and 8 more
- 8T0Y · TRPV1 in nanodisc bound with one LPA in one monomer · NKN D901 · binds TYR511, SER512, LEU515, PHE522, PHE543, ALA546, MET547, THR550 and 10 more
- 8T10 · TRPV1 in nanodisc bound with two LPA molecules in opposite monomers · NKN A901 · binds TYR511, SER512, LEU515, PHE522, PHE543, ALA546, MET547, THR550 and 9 more
- 8T3L · TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers · NKN B801 · binds PHE587, PHE591, ILE661, ALA665, LEU669, TYR511, SER512, LEU515 and 9 more
- 8T3M · TRPV1 in nanodisc bound with 3 LPA molecules · NKN D801 · binds TYR511, SER512, LEU515, PHE543, ALA546, MET547, THR550, ASN551 and 9 more
- 3NKN · Crystal structure of mouse autotaxin in complex with 14:0-lpa · NKN A1006 · binds ILE167, SER169, ASP171, LYS208, THR209, PHE210, LEU213, LEU216 and 12 more
- 3QCU · Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic… · NKN H215 · binds LEU33, LEU50, ASN52, TYR56, PHE96, GLY97, TYR98, TYR99 and 13 more
- 3SAO · The siderocalin ex-fabp functions through dual ligand specificities · NKN A161 · binds VAL8, TRP12, ILE14, ILE38, LEU46, VAL48, TYR50, PHE65 and 10 more
- 4ZG7 · Structural basis for inhibition of human autotaxin by four novel compounds · NKN A909 · binds ILE168, SER170, ASP172, LYS209, THR210, PHE211, LEU214, LEU217 and 15 more
Residues it binds most
PHE 23, TYR 25, LEU 23, ILE 18, ASN 19, ALA 19, SER 18, VAL 5, MET 15, THR 15 (residue and the binding sites it lines).
Found with
- NA · Sodium ion
- 8IJ · (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate
- CA · Calcium ion
- ZN · Zinc ion
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
- GOL · Glycerol
- DBH · 2,3-dihydroxy-benzoic acid
- FE · Fe (III) ion
- K · Potassium ion
- BMA · beta-D-mannopyranose
- MAN · alpha-D-mannopyranose
- SCN · Thiocyanate ion
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