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Ligand · CLR

CLR · Cholesterol

CLR, Cholesterol (C27 H46 O, 386.6 g/mol), in the MolNFT structures on GenesisL1: bound in 903 records (667 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
CLR
Formula
C27 H46 O
Class
ligand
Structures
903
PDB entries
667

Binding sites

CLR in 903 structures; the first of them:

  • 4XNV · The human P2Y1 receptor in complex with BPTU · CLR A1102 · binds ILE178, VAL181, ALA182, PRO185, TYR189, SER213, ILE216, TYR217 and 1 more
  • 4XP1 · X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine · CLR A711 · binds VAL34, LEU37, LEU38, LEU270, TYR273, LEU276, LEU277, LEU280 and 2 more
  • 4XP4 · X-ray structure of Drosophila dopamine transporter in complex with cocaine · CLR A705 · binds VAL34, LEU37, LEU38, LEU270, TYR273, LEU276, LEU277, LEU280 and 2 more
  • 4XP9 · X-ray structure of Drosophila dopamine transporter bound to psychostimulant D-amphetamine · CLR C705 · binds VAL34, LEU37, LEU38, ILE41, LEU270, TYR273, LEU276, LEU277 and 3 more
  • 4XPA · X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine · CLR A701 · binds VAL34, LEU37, LEU38, LEU270, TYR273, LEU276, LEU277, LEU280 and 2 more
  • 5AVS · Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+… · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AVT · Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+… · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AVY · Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+… · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AVZ · Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+… · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AW0 · Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+… · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AW6 · Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+… · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AW8 · Kinetics by X-ray crystallography: E2.MgF42-.2RB+ crystal · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5AW9 · Kinetics by X-ray crystallography: native E2.MgF42-.2K+ crystal for Rb+ bound crystals · CLR B3001 · binds THR788, LEU791, GLU847, ILE850, SER851, TYR854, GLY855, MET859 and 5 more
  • 5C1M · Crystal structure of active mu-opioid receptor bound to the agonist BU72 · CLR A403 · binds ILE290, VAL291, THR294, PRO295, ILE298, TYR299, ILE302, ILE308 and 4 more
  • 5D5A · In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor… · CLR A1206 · binds TYR70, THR73, CYS77, LEU115, ARG151, ILE154, TRP158
  • 5D5B · In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K · CLR A1205 · binds TYR70, THR73, SER74, CYS77, VAL81, ILE112, LEU115, ARG151 and 3 more
  • 5D6L · beta2AR-T4L - CIM · CLR A1212 · binds TYR70, THR73, SER74, CYS77, VAL81, PHE108, ILE112, LEU115 and 5 more
  • 5I6X · X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the… · CLR A702 · binds TYR572, TRP573, ILE576, LEU577, ALA580
  • 5I71 · X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the… · CLR A703 · binds TRP573, LEU577, ALA580
  • 5I73 · X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the… · CLR A703 · binds TRP573, LEU577, ALA580
  • 5I74 · X-ray structure of the ts3 human serotonin transporter complexed with Br-citalopram at… · CLR A702 · binds TRP573, LEU577, ALA580
  • 5I75 · X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the… · CLR A703 · binds TRP573, LEU577, ALA580
  • 5IU4 · Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with… · CLR A2402 · binds HIS75, GLY76, PHE79, PHE133, MET140
  • 5IU7 · Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with… · CLR A2402 · binds ALA73, HIS75, GLY76, PHE79, MET140
  • 5IU8 · Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with… · CLR A2403 · binds PHE62, ALA72, ALA73, GLY76, PHE79, ILE80

Residues it binds most

LEU 2345, PHE 2034, ILE 2079, VAL 1591, TYR 1253, ALA 1099, TRP 1149, THR 862, SER 840, MET 727 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • NA · Sodium ion
  • OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
  • MG · Magnesium ion
  • OLA · Oleic acid
  • BMA · beta-D-mannopyranose
  • PLM · Palmitic acid
  • PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine
  • CA · Calcium ion
  • MAN · alpha-D-mannopyranose
  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
  • Y01 · Cholesterol hemisuccinate

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