6IY · (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate

Binding sites

6IY in 7 structures; the first of them:

• 7L2S · cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state · 6IY D802 · binds LYS656, LEU664, MET581, TYR631, CYS634, PHE638
• 7L2X · cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state c · 6IY A902 · binds MET581, TYR584, LEU588, SER629, TYR631, SER632, CYS634, LEU635 and 7 more
• 7L2P · Cryo-EM structure of unliganded minimal TRPV1 · 6IY A802 · binds MET581, LEU585, LEU630, TYR631, SER632, CYS634, LEU635, PHE638 and 5 more
• 7L2S · Cryo-EM structure of dktx-bound minimal TRPV1 at the pre-bound state · 6IY D802 · binds LYS656, LEU664, MET581, TYR631, CYS634, PHE638
• 7L2W · Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state a · 6IY A902 · binds TYR631, LYS656, ILE660, ILE661, ILE668
• 7L2X · Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state C · 6IY A902 · binds TYR631, SER632, LEU635, PHE638, ALA657, ILE660, ILE661
• 7MZ6 · Cryo-EM structure of minimal TRPV1 with 1 perturbed pi · 6IY A802 · binds LEU585, LEU588, TYR631, SER632, PHE638, LEU664

Residues it binds most

LEU 20, ILE 21, TYR 28, PHE 24, LYS 21, ALA 14, CYS 14, MET 14, SER 11 (residue and the binding sites it lines).

Found with

• NA · Sodium ion
• XJ7 · (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2r,3s,4s,5r, 6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate
• 6EU · resiniferatoxin
• XPJ · 1-deoxy-1-(methylamino)-D-allitol