MolNFT v1 · #173218 · protein

Apo human RNA polymerase III

7AST · DNA-directed RNA polymerase III subunit RPC1: “Apo human RNA polymerase III”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #173218 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7AST
Type: protein
Length: 4,401 residues
Chains: 17
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-directed RNA polymerase III subunit RPC1; DNA-directed RNA polymerase III subunit…
EC: 2.7.7.6
UniProt: O14802, Q9Y2Y1, P62875, P53803, P52434, P61218, P19388, P0DPB6, O15160, O75575, Q9Y535, Q9NVU0, P05423, Q9NW08, Q9H1D9, Q9BUI4
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 17 distinct chains · 28% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
N	DNA-directed RNA polymerase III subunit RPC1 (EC 2.7.7.6)	protein	1238	28% helix, 3% strand	O14802
A	DNA-directed RNA polymerase III subunit RPC10	protein	37	0% helix, 11% strand	Q9Y2Y1
B	DNA-directed RNA polymerases I, II, and III subunit RPABC5	protein	64	34% helix, 5% strand	P62875
C	DNA-directed RNA polymerases I, II, and III subunit RPABC4	protein	46	0% helix, 22% strand	P53803
D	DNA-directed RNA polymerases I, II, and III subunit RPABC3	protein	121	0% helix, 12% strand	P52434
E	DNA-directed RNA polymerases I, II, and III subunit RPABC2	protein	81	26% helix, 12% strand	P61218
F	DNA-directed RNA polymerases I, II, and III subunit RPABC1	protein	209	31% helix, 10% strand	P19388
G	DNA-directed RNA polymerases I and III subunit RPAC2	protein	100	35% helix, 17% strand	P0DPB6
H	DNA-directed RNA polymerases I and III subunit RPAC1	protein	329	19% helix, 17% strand	O15160
I	DNA-directed RNA polymerase III subunit RPC9	protein	125	58% helix, 2% strand	O75575
J	DNA-directed RNA polymerase III subunit RPC8	protein	179	7% helix, 20% strand	Q9Y535
K	DNA-directed RNA polymerase III subunit RPC5	protein	137	9% helix, 18% strand	Q9NVU0
L	DNA-directed RNA polymerase III subunit RPC4	protein	82	4% helix, 11% strand	P05423
M	DNA-directed RNA polymerase III subunit RPC2 (EC 2.7.7.6)	protein	1114	22% helix, 12% strand	Q9NW08
Z	DNA-directed RNA polymerase III subunit RPC6	protein	63	46% helix, 3% strand	Q9H1D9
X	DNA-directed RNA polymerase III subunit RPC3	protein	440	67% helix, 5% strand	Q9BUI4
Y	DNA-directed RNA polymerase III subunit RPC7-beta	protein	36	44% helix, 0% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	703	0.82	0.86	86	empty
2	1023	0.82	0.83	113	empty
3	1028	0.81	0.82	119	empty
4	906	0.81	0.83	92	empty
5	1092	0.81	0.82	109	empty

Interfaces

32 interfaces between chains.

N–M · 9234 Å² buried · 90 hydrogen bonds · protein-protein
K–L · 2145 Å² buried · 42 hydrogen bonds · protein-protein
I–J · 1973 Å² buried · 26 hydrogen bonds · protein-protein
G–H · 1958 Å² buried · 22 hydrogen bonds · protein-protein
N–E · 1901 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

7AST · Apo Human RNA Polymerase III · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14802
Every structure of UniProt Q9Y2Y1
Every structure of UniProt P62875
Every structure of UniProt P53803
Every structure of UniProt P52434
Every structure of UniProt P61218
Every structure of UniProt P19388
Every structure of UniProt P0DPB6
Every structure of UniProt O15160
Every structure of UniProt O75575
Every structure of UniProt Q9Y535
Every structure of UniProt Q9NVU0
Every structure of UniProt P05423
Every structure of UniProt Q9NW08
Every structure of UniProt Q9H1D9
Every structure of UniProt Q9BUI4
Elsewhere: RCSB PDB 7AST · PDBe 7AST · UniProt O14802 · UniProt Q9Y2Y1 · UniProt P62875 · UniProt P53803 · UniProt P52434 · UniProt P61218 · UniProt P19388 · UniProt P0DPB6 · UniProt O15160 · UniProt O75575 · UniProt Q9Y535 · UniProt Q9NVU0 · UniProt P05423 · UniProt Q9NW08 · UniProt Q9H1D9 · UniProt Q9BUI4

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