Research workbench
Apo human RNA polymerase III
Analyse Apo human RNA polymerase III in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AST
- Type
- protein
- Length
- 4,401 residues
- Chains
- 17
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-directed RNA polymerase III subunit RPC1; DNA-directed RNA polymerase III subunit…
- EC
- 2.7.7.6
- UniProt
- O14802, Q9Y2Y1, P62875, P53803, P52434, P61218, P19388, P0DPB6, O15160, O75575, Q9Y535, Q9NVU0, P05423, Q9NW08, Q9H1D9, Q9BUI4
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 17 distinct chains · 28% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| N | DNA-directed RNA polymerase III subunit RPC1 (EC 2.7.7.6) | protein | 1238 | 28% helix, 3% strand | O14802 |
| A | DNA-directed RNA polymerase III subunit RPC10 | protein | 37 | 0% helix, 11% strand | Q9Y2Y1 |
| B | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | protein | 64 | 34% helix, 5% strand | P62875 |
| C | DNA-directed RNA polymerases I, II, and III subunit RPABC4 | protein | 46 | 0% helix, 22% strand | P53803 |
| D | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | protein | 121 | 0% helix, 12% strand | P52434 |
| E | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | protein | 81 | 26% helix, 12% strand | P61218 |
| F | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | protein | 209 | 31% helix, 10% strand | P19388 |
| G | DNA-directed RNA polymerases I and III subunit RPAC2 | protein | 100 | 35% helix, 17% strand | P0DPB6 |
| H | DNA-directed RNA polymerases I and III subunit RPAC1 | protein | 329 | 19% helix, 17% strand | O15160 |
| I | DNA-directed RNA polymerase III subunit RPC9 | protein | 125 | 58% helix, 2% strand | O75575 |
| J | DNA-directed RNA polymerase III subunit RPC8 | protein | 179 | 7% helix, 20% strand | Q9Y535 |
| K | DNA-directed RNA polymerase III subunit RPC5 | protein | 137 | 9% helix, 18% strand | Q9NVU0 |
| L | DNA-directed RNA polymerase III subunit RPC4 | protein | 82 | 4% helix, 11% strand | P05423 |
| M | DNA-directed RNA polymerase III subunit RPC2 (EC 2.7.7.6) | protein | 1114 | 22% helix, 12% strand | Q9NW08 |
| Z | DNA-directed RNA polymerase III subunit RPC6 | protein | 63 | 46% helix, 3% strand | Q9H1D9 |
| X | DNA-directed RNA polymerase III subunit RPC3 | protein | 440 | 67% helix, 5% strand | Q9BUI4 |
| Y | DNA-directed RNA polymerase III subunit RPC7-beta | protein | 36 | 44% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 703 | 0.82 | 0.86 | 86 | empty |
| 2 | 1023 | 0.82 | 0.83 | 113 | empty |
| 3 | 1028 | 0.81 | 0.82 | 119 | empty |
| 4 | 906 | 0.81 | 0.83 | 92 | empty |
| 5 | 1092 | 0.81 | 0.82 | 109 | empty |
Interfaces
32 interfaces between chains.
- N–M · 9234 Ų buried · 90 hydrogen bonds · protein-protein
- K–L · 2145 Ų buried · 42 hydrogen bonds · protein-protein
- I–J · 1973 Ų buried · 26 hydrogen bonds · protein-protein
- G–H · 1958 Ų buried · 22 hydrogen bonds · protein-protein
- N–E · 1901 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 7AST · Apo Human RNA Polymerase III · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14802
- Every structure of UniProt Q9Y2Y1
- Every structure of UniProt P62875
- Every structure of UniProt P53803
- Every structure of UniProt P52434
- Every structure of UniProt P61218
- Every structure of UniProt P19388
- Every structure of UniProt P0DPB6
- Every structure of UniProt O15160
- Every structure of UniProt O75575
- Every structure of UniProt Q9Y535
- Every structure of UniProt Q9NVU0
- Every structure of UniProt P05423
- Every structure of UniProt Q9NW08
- Every structure of UniProt Q9H1D9
- Every structure of UniProt Q9BUI4
- Elsewhere: RCSB PDB 7AST · PDBe 7AST · UniProt O14802 · UniProt Q9Y2Y1 · UniProt P62875 · UniProt P53803 · UniProt P52434 · UniProt P61218 · UniProt P19388 · UniProt P0DPB6 · UniProt O15160 · UniProt O75575 · UniProt Q9Y535 · UniProt Q9NVU0 · UniProt P05423 · UniProt Q9NW08 · UniProt Q9H1D9 · UniProt Q9BUI4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.