UniProt Q9H1D9
DNA-directed RNA polymerase III subunit RPC6 (Q9H1D9)
DNA-directed RNA polymerase III subunit RPC6 (UniProt Q9H1D9): 27 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9H1D9
- Protein
- DNA-directed RNA polymerase III subunit RPC6
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 37 · 14 records with a druggable one
Structures
28 records of Q9H1D9 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DK5 | Solution structure of Winged-Helix domain in RNA polymerase III 39KDa polypeptide | solution nmr | A | — | — |
| 2DK5 | Solution structure of winged-helix domain in RNA polymerase III 39KDA polypeptide | solution nmr | A | — | — |
| 7A6H | Cryo-EM structure of human apo RNA Polymerase III | electron microscopy | P | SF4 | 4 (best 0.82) |
| 7A6H | Cryo-EM structure of human apo RNA polymerase III | electron microscopy | P | SF4 | — |
| 7AE1 | Cryo-EM structure of human RNA Polymerase III elongation complex 1 | electron microscopy | P | SF4 | 2 (best 0.82) |
| 7AE1 | Cryo-EM structure of human RNA polymerase III elongation complex 1 | electron microscopy | P | SF4 | — |
| 7AE3 | Cryo-EM structure of human RNA Polymerase III elongation complex 3 | electron microscopy | P | SF4 | 3 (best 0.85) |
| 7AE3 | Cryo-EM structure of human RNA polymerase III elongation complex 3 | electron microscopy | P | SF4 | — |
| 7AEA | Cryo-EM structure of human RNA Polymerase III elongation complex 2 | electron microscopy | P | SF4 | 4 (best 0.83) |
| 7AEA | Cryo-EM structure of human RNA polymerase III elongation complex 2 | electron microscopy | P | SF4 | — |
| 7AST | Apo Human RNA Polymerase III | electron microscopy | Z | — | 1 (best 0.67) |
| 7AST | Apo human RNA polymerase III | electron microscopy | Z | — | — |
| 7D58 | cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | P | SF4 | 1 (best 0.81) |
| 7D58 | Cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | P | SF4 | — |
| 7D59 | cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | P | SF4 | 1 (best 0.81) |
| 7D59 | Cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | P | SF4 | — |
| 7DN3 | Structure of Human RNA Polymerase III elongation complex | electron microscopy | P | SF4 | 3 (best 0.81) |
| 7DN3 | Structure of human RNA polymerase III elongation complex | electron microscopy | P | SF4 | — |
| 7DU2 | RNA polymerase III EC complex in post-translocation state | electron microscopy | P | SF4 | 4 (best 0.83) |
| 7DU2 | RNA polymerase III ec complex in post-translocation state | electron microscopy | P | SF4 | — |
| 7FJI | human Pol III elongation complex | electron microscopy | P | SF4 | 3 (best 0.80) |
| 7FJI | Human pol III elongation complex | electron microscopy | P | SF4 | — |
| 7FJJ | human Pol III pre-termination complex | electron microscopy | P | SF4 | 4 (best 0.82) |
| 7FJJ | Human pol III pre-termination complex | electron microscopy | P | SF4 | — |
| 8ITY | human RNA polymerase III pre-initiation complex closed DNA 1 | electron microscopy | P | SF4 | 1 (best 0.86) |
| 8IUE | RNA polymerase III pre-initiation complex melting complex 1 | electron microscopy | P | SF4 | 2 (best 0.81) |
| 8IUH | RNA polymerase III pre-initiation complex open complex 1 | electron microscopy | P | SF4 | 3 (best 0.82) |
| Q9H1D9 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC6 (Q9H1D9) | predicted | A | — | 1 (best 0.28) |
Ligands
- SF4 · Iron/sulfur cluster · in 23 records
Experiment against prediction
- 7AST chain Z against the predicted model Q9H1D9: TM-score 0.75, RMSD 1.82 Å
- 7AST chain Z against the predicted model Q9H1D9: TM-score 0.75, RMSD 1.82 Å
- 2DK5 chain A against the predicted model Q9H1D9: TM-score 0.73, RMSD 1.75 Å
- 2DK5 chain A against the predicted model Q9H1D9: TM-score 0.73, RMSD 1.75 Å
- 8ITY chain P against the predicted model Q9H1D9: TM-score 0.73, RMSD 3.04 Å
- 7A6H chain P against the predicted model Q9H1D9: TM-score 0.70, RMSD 2.62 Å
- 7A6H chain P against the predicted model Q9H1D9: TM-score 0.70, RMSD 2.62 Å
- 7AE3 chain P against the predicted model Q9H1D9: TM-score 0.70, RMSD 2.64 Å
- 7AE3 chain P against the predicted model Q9H1D9: TM-score 0.70, RMSD 2.64 Å
- 7AEA chain P against the predicted model Q9H1D9: TM-score 0.69, RMSD 2.67 Å
Elsewhere
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