UniProt P05423
DNA-directed RNA polymerase III subunit RPC4 (P05423)
DNA-directed RNA polymerase III subunit RPC4 (UniProt P05423): 20 experimental structures and 1 predicted model on GenesisL1, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05423
- Protein
- DNA-directed RNA polymerase III subunit RPC4
- Experimental structures
- 20
- Predicted models
- 1
- Pockets
- 24 · 10 records with a druggable one
Structures
21 records of P05423 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7A6H | Cryo-EM structure of human apo RNA polymerase III | electron microscopy | N | — | — |
| 7AE1 | Cryo-EM structure of human RNA Polymerase III elongation complex 1 | electron microscopy | N | — | 3 (best 0.76) |
| 7AE1 | Cryo-EM structure of human RNA polymerase III elongation complex 1 | electron microscopy | N | — | — |
| 7AE3 | Cryo-EM structure of human RNA Polymerase III elongation complex 3 | electron microscopy | N | — | 3 (best 0.77) |
| 7AE3 | Cryo-EM structure of human RNA polymerase III elongation complex 3 | electron microscopy | N | — | — |
| 7AEA | Cryo-EM structure of human RNA Polymerase III elongation complex 2 | electron microscopy | N | — | 4 (best 0.76) |
| 7AEA | Cryo-EM structure of human RNA polymerase III elongation complex 2 | electron microscopy | N | — | — |
| 7AST | Apo Human RNA Polymerase III | electron microscopy | L | — | 1 (best 0.67) |
| 7AST | Apo human RNA polymerase III | electron microscopy | L | — | — |
| 7D58 | cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | N | — | 3 (best 0.79) |
| 7D58 | Cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | N | — | — |
| 7D59 | cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | N | — | 3 (best 0.81) |
| 7D59 | Cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | N | — | — |
| 7DN3 | Structure of human RNA polymerase III elongation complex | electron microscopy | N | — | — |
| 7DU2 | RNA polymerase III ec complex in post-translocation state | electron microscopy | N | — | — |
| 7FJI | human Pol III elongation complex | electron microscopy | N | — | 2 (best 0.76) |
| 7FJI | Human pol III elongation complex | electron microscopy | N | — | — |
| 7FJJ | human Pol III pre-termination complex | electron microscopy | N | — | 2 (best 0.71) |
| 7FJJ | Human pol III pre-termination complex | electron microscopy | N | — | — |
| 8IUE | RNA polymerase III pre-initiation complex melting complex 1 | electron microscopy | N | — | 2 (best 0.77) |
| P05423 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC4 (P05423) | predicted | A | — | 1 (best 0.56) |
Experiment against prediction
- 7DU2 chain N against the predicted model P05423: TM-score 0.83, RMSD 1.89 Å
- 7DN3 chain N against the predicted model P05423: TM-score 0.83, RMSD 1.89 Å
- 8IUE chain N against the predicted model P05423: TM-score 0.79, RMSD 2.61 Å
- 7FJJ chain N against the predicted model P05423: TM-score 0.79, RMSD 2.50 Å
- 7FJJ chain N against the predicted model P05423: TM-score 0.79, RMSD 2.50 Å
- 7FJI chain N against the predicted model P05423: TM-score 0.79, RMSD 2.50 Å
- 7FJI chain N against the predicted model P05423: TM-score 0.79, RMSD 2.50 Å
- 7D58 chain N against the predicted model P05423: TM-score 0.78, RMSD 2.41 Å
- 7D58 chain N against the predicted model P05423: TM-score 0.78, RMSD 2.41 Å
- 7D59 chain N against the predicted model P05423: TM-score 0.78, RMSD 2.41 Å
Elsewhere
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