UniProt O14802
DNA-directed RNA polymerase III subunit RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (UniProt O14802), EC 2.7.7.6: 18 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 109 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O14802
- Protein
- DNA-directed RNA polymerase III subunit RPC1
- EC
- 2.7.7.6
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 109 · 8 records with a druggable one
Structures
19 records of O14802 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7A6H | Cryo-EM structure of human apo RNA polymerase III | electron microscopy | A | ZN, MG | — |
| 7AE1 | Cryo-EM structure of human RNA Polymerase III elongation complex 1 | electron microscopy | A | ZN, MG | 15 (best 0.85) |
| 7AE1 | Cryo-EM structure of human RNA polymerase III elongation complex 1 | electron microscopy | A | ZN, MG | — |
| 7AE3 | Cryo-EM structure of human RNA Polymerase III elongation complex 3 | electron microscopy | A | ZN, MG | 15 (best 0.85) |
| 7AE3 | Cryo-EM structure of human RNA polymerase III elongation complex 3 | electron microscopy | A | ZN, MG | — |
| 7AEA | Cryo-EM structure of human RNA Polymerase III elongation complex 2 | electron microscopy | A | ZN, MG | 15 (best 0.83) |
| 7AEA | Cryo-EM structure of human RNA polymerase III elongation complex 2 | electron microscopy | A | ZN, MG | — |
| 7AST | Apo human RNA polymerase III | electron microscopy | N | — | — |
| 7D58 | Cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | A | ZN | — |
| 7D59 | cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | A | ZN | 14 (best 0.86) |
| 7D59 | Cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | A | ZN | — |
| 7DN3 | Structure of human RNA polymerase III elongation complex | electron microscopy | A | MG, ZN | — |
| 7DU2 | RNA polymerase III ec complex in post-translocation state | electron microscopy | A | MG, ZN | — |
| 7FJI | human Pol III elongation complex | electron microscopy | A | ZN | 16 (best 0.86) |
| 7FJI | Human pol III elongation complex | electron microscopy | A | ZN | — |
| 7FJJ | Human pol III pre-termination complex | electron microscopy | A | MG, ZN | — |
| 8ITY | human RNA polymerase III pre-initiation complex closed DNA 1 | electron microscopy | A | ZN, MG | 8 (best 0.86) |
| 8IUE | RNA polymerase III pre-initiation complex melting complex 1 | electron microscopy | A | ZN, MG | 10 (best 0.84) |
| O14802 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC1 (O14802) | predicted | A | — | 16 (best 0.72) |
Ligands
Experiment against prediction
- 7DN3 chain A against the predicted model O14802: TM-score 0.99, RMSD 1.38 Å
- 7DU2 chain A against the predicted model O14802: TM-score 0.99, RMSD 1.38 Å
- 7FJI chain A against the predicted model O14802: TM-score 0.98, RMSD 1.65 Å
- 7FJI chain A against the predicted model O14802: TM-score 0.98, RMSD 1.65 Å
- 7FJJ chain A against the predicted model O14802: TM-score 0.98, RMSD 1.73 Å
- 7AE3 chain A against the predicted model O14802: TM-score 0.98, RMSD 1.79 Å
- 7AE3 chain A against the predicted model O14802: TM-score 0.98, RMSD 1.79 Å
- 7AE1 chain A against the predicted model O14802: TM-score 0.98, RMSD 1.95 Å
- 7AE1 chain A against the predicted model O14802: TM-score 0.98, RMSD 1.95 Å
- 7AEA chain A against the predicted model O14802: TM-score 0.98, RMSD 1.95 Å
Elsewhere
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