MolNFT v1 · #385053 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC1 (O14802)
O14802: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC1 (O14802)”. 16 pockets (best druggability 0.72). MolNFT v1 #385053 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O14802
- Type
- protein
- Length
- 1,390 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xfb0568570325C9C3F26f51e3A07C58ee55079e46
- Molecule
- DNA-directed RNA polymerase III subunit RPC1
- UniProt
- O14802
- Pockets
- 16 · best druggability 0.72
Structure
1 distinct chain · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase III subunit RPC1 | protein | 1390 | 45% helix, 14% strand | O14802 |
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 579 | 0.72 | 0.79 | 40 | empty |
| 2 | 806 | 0.71 | 0.77 | 66 | empty |
| 3 | 477 | 0.64 | 0.77 | 53 | empty |
| 4 | 578 | 0.63 | 0.75 | 62 | empty |
| 5 | 256 | 0.54 | 0.77 | 30 | empty |
Compared structures
- 7AE1 · Cryo-EM structure of human RNA Polymerase III elongation complex 1 · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7AE1 · Cryo-EM structure of human RNA polymerase III elongation complex 1 · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7AEA · Cryo-EM structure of human RNA Polymerase III elongation complex 2 · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7AEA · Cryo-EM structure of human RNA polymerase III elongation complex 2 · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 8IUE · RNA polymerase III pre-initiation complex melting complex 1 · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7FJI · human Pol III elongation complex · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7FJI · Human pol III elongation complex · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7D58 · Cryo-EM structure of human RNA polymerase III in elongating state · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7AE3 · Cryo-EM structure of human RNA polymerase III elongation complex 3 · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 7FJJ · Human pol III pre-termination complex · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 8ITY · human RNA polymerase III pre-initiation complex closed DNA 1 · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 7A6H · Cryo-EM structure of human apo RNA polymerase III · an experimental structure of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14802
- Elsewhere: UniProt O14802 · AlphaFold DB O14802
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