UniProt O15160
DNA-directed RNA polymerases I and III subunit RPAC1 (O15160)
DNA-directed RNA polymerases I and III subunit RPAC1 (UniProt O15160): 21 experimental structures and 1 predicted model on GenesisL1, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15160
- Protein
- DNA-directed RNA polymerases I and III subunit RPAC1
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 18 · 6 records with a druggable one
Structures
22 records of O15160 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7A6H | Cryo-EM structure of human apo RNA polymerase III | electron microscopy | C | — | — |
| 7AE1 | Cryo-EM structure of human RNA Polymerase III elongation complex 1 | electron microscopy | C | — | 4 (best 0.81) |
| 7AE1 | Cryo-EM structure of human RNA polymerase III elongation complex 1 | electron microscopy | C | — | — |
| 7AE3 | Cryo-EM structure of human RNA polymerase III elongation complex 3 | electron microscopy | C | — | — |
| 7AEA | Cryo-EM structure of human RNA Polymerase III elongation complex 2 | electron microscopy | C | — | 3 (best 0.82) |
| 7AEA | Cryo-EM structure of human RNA polymerase III elongation complex 2 | electron microscopy | C | — | — |
| 7AST | Apo human RNA polymerase III | electron microscopy | H | — | — |
| 7D58 | Cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | C | — | — |
| 7D59 | Cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | C | — | — |
| 7DN3 | Structure of human RNA polymerase III elongation complex | electron microscopy | C | — | — |
| 7DU2 | RNA polymerase III ec complex in post-translocation state | electron microscopy | C | — | — |
| 7FJI | human Pol III elongation complex | electron microscopy | C | — | 3 (best 0.83) |
| 7FJI | Human pol III elongation complex | electron microscopy | C | — | — |
| 7FJJ | Human pol III pre-termination complex | electron microscopy | C | — | — |
| 7OB9 | Cryo-EM structure of human RNA polymerase I in elongation state | electron microscopy | C | — | — |
| 7OBA | Cryo-EM structure of human RNA polymerase I in complex with RRN3 | electron microscopy | C | — | — |
| 7OBB | Cryo-EM structure of human RNA polymerase I open complex | electron microscopy | C | — | — |
| 7VBA | Structure of the pre state human RNA Polymerase I Elongation Complex | electron microscopy | C | — | — |
| 8A43 | Human RNA polymerase I | electron microscopy | C | — | 4 (best 0.82) |
| 8A43 | Human RNA polymerase I | electron microscopy | C | — | — |
| 8IUE | RNA polymerase III pre-initiation complex melting complex 1 | electron microscopy | C | — | 3 (best 0.83) |
| O15160 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases I and III subunit RPAC1 (O15160) | predicted | A | — | 1 (best 0.51) |
Experiment against prediction
- 7FJI chain C against the predicted model O15160: TM-score 0.99, RMSD 0.59 Å
- 7FJI chain C against the predicted model O15160: TM-score 0.99, RMSD 0.59 Å
- 7FJJ chain C against the predicted model O15160: TM-score 0.99, RMSD 0.60 Å
- 7A6H chain C against the predicted model O15160: TM-score 0.99, RMSD 0.70 Å
- 7AE1 chain C against the predicted model O15160: TM-score 0.99, RMSD 0.70 Å
- 7AE1 chain C against the predicted model O15160: TM-score 0.99, RMSD 0.70 Å
- 7AE3 chain C against the predicted model O15160: TM-score 0.99, RMSD 0.71 Å
- 8IUE chain C against the predicted model O15160: TM-score 0.99, RMSD 0.71 Å
- 7AEA chain C against the predicted model O15160: TM-score 0.99, RMSD 0.74 Å
- 7AEA chain C against the predicted model O15160: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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