MolNFT v2 · #197651 · protein + DNA + RNA
Structure of the pre state human RNA Polymerase I Elongation Complex
7VBA: “Structure of the pre state human RNA Polymerase I Elongation Complex”. Electron microscopy at 2.89, 3 ligands (2TM, ZN, MG). MolNFT v2 #197651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7VBA
- Type
- protein + DNA + RNA
- Length
- 4,091 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.89
- Source
- Homo sapiens
- UniProt
- O95602, Q9H9Y6, O15160, P19388, P61218, P52434, Q9P1U0, P62875, P0DPB6, P53803, O15446, Q3B726, Q9GZS1
- Ligands
- 2TM, ZN, MG
Structure
electron microscopy · resolution 2.89 · 16 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1473 | — | O95602 |
| B | — | protein | 1123 | — | Q9H9Y6 |
| C | — | protein | 337 | — | O15160 |
| E | — | protein | 199 | — | P19388 |
| F | — | protein | 76 | — | P61218 |
| H | — | protein | 146 | — | P52434 |
| I | — | protein | 60 | — | Q9P1U0 |
| J | — | protein | 64 | — | P62875 |
| K | — | protein | 108 | — | P0DPB6 |
| L | — | protein | 45 | — | P53803 |
| N | — | protein | 151 | — | O15446 |
| G | — | protein | 157 | — | Q3B726 |
| M | — | protein | 110 | — | Q9GZS1 |
| R | — | rna | 8 | — | — |
| T | — | dna | 22 | — | — |
| U | — | dna | 12 | — | — |
Ligands and binding sites
- 2TM · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]cytidine · ligand · chains A, B, R, T
- ZN · Zinc ion · metal · 5 copies · chains A, B, J, L
- MG · Magnesium ion · metal · chains A, R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- Q9H9Y6 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA2 (Q9H9Y6) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P19388 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases I, II, and III subunit… · a predicted model of the same protein · chain E against A, TM-score 0.98
- O15160 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases I and III subunit… · a predicted model of the same protein · chain C against A, TM-score 0.98
- P0DPB6 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases I and III subunit… · a predicted model of the same protein · chain K against A, TM-score 0.94
- Q9GZS1 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q9GZS1) · a predicted model of the same protein · chain M against A, TM-score 0.92
- O15446 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA34 (O15446) · a predicted model of the same protein · chain N against A, TM-score 0.70
- Q9P1U0 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA12 (Q9P1U0) · a predicted model of the same protein · chain I against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95602
- Every structure of UniProt Q9H9Y6
- Every structure of UniProt O15160
- Every structure of UniProt P19388
- Every structure of UniProt P61218
- Every structure of UniProt P52434
- Every structure of UniProt Q9P1U0
- Every structure of UniProt P62875
- Every structure of UniProt P0DPB6
- Every structure of UniProt P53803
- Every structure of UniProt O15446
- Every structure of UniProt Q3B726
- Every structure of UniProt Q9GZS1
- Elsewhere: RCSB PDB 7VBA · PDBe 7VBA · UniProt O95602 · UniProt Q9H9Y6 · UniProt O15160 · UniProt P19388 · UniProt P61218 · UniProt P52434 · UniProt Q9P1U0 · UniProt P62875 · UniProt P0DPB6 · UniProt P53803 · UniProt O15446 · UniProt Q3B726 · UniProt Q9GZS1
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