MolNFT v1 · #384866 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases I, II, and III subunit RPABC1 (P19388)
P19388: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases I, II, and III subunit RPABC1 (P19388)”. 2 pockets (best druggability 0.47). MolNFT v1 #384866 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P19388
- Type
- protein
- Length
- 210 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x217424F9DaBCc393943B589f669cf48C9cf3A079
- Molecule
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- UniProt
- P19388
- Pockets
- 2 · best druggability 0.47
Structure
1 distinct chain · 42% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | protein | 210 | 42% helix, 25% strand | P19388 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.47 | 0.75 | 20 | empty |
| 2 | 119 | 0.42 | 0.76 | 20 | empty |
Compared structures
- 7OB9 · Cryo-EM structure of human RNA polymerase I in elongation state · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 7OB9 · Cryo-EM structure of human RNA Polymerase I in elongation state · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 7OBB · Cryo-EM structure of human RNA polymerase I open complex · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 7OBB · Cryo-EM structure of human RNA Polymerase I Open Complex · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 7OBA · Cryo-EM structure of human RNA polymerase I in complex with RRN3 · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 7OBA · Cryo-EM structure of human RNA Polymerase I in complex with RRN3 · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 7LBM · Structure of the human Mediator-bound transcription pre-initiation complex · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 5IY8 · Human holo-pic in the initial transcribing state · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 5IY8 · Human holo-PIC in the initial transcribing state · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 5IYC · Human core-pic in the initial transcribing state · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 5IYC · Human core-PIC in the initial transcribing state · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 5IYD · Human core-pic in the initial transcribing state (no iis) · an experimental structure of the same protein · chain A against E, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19388
- Elsewhere: UniProt P19388 · AlphaFold DB P19388
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