MolNFT v1 · #384854 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q9GZS1)
Q9GZS1: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q9GZS1)”. 4 pockets (best druggability 0.56). MolNFT v1 #384854 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9GZS1
- Type
- protein
- Length
- 419 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB3159EE53D53042c0C9Eb6793e5F61743EAca5Ed
- Molecule
- DNA-directed RNA polymerase I subunit RPA49
- UniProt
- Q9GZS1
- Pockets
- 4 · best druggability 0.56
Structure
1 distinct chain · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase I subunit RPA49 | protein | 419 | 45% helix, 20% strand | Q9GZS1 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.56 | 0.78 | 28 | empty |
| 2 | 142 | 0.42 | 0.75 | 28 | empty |
| 3 | 82 | 0.33 | 0.74 | 16 | empty |
| 4 | 55 | 0.27 | 0.73 | 16 | empty |
Compared structures
- 7OB9 · Cryo-EM structure of human RNA polymerase I in elongation state · an experimental structure of the same protein · chain A against M, TM-score 0.42
- 7VBA · Structure of the pre state human RNA Polymerase I Elongation Complex · an experimental structure of the same protein · chain A against M, TM-score 0.25
- 8A43 · Human RNA polymerase I · an experimental structure of the same protein · chain A against N, TM-score 0.25
- 8A43 · Human RNA polymerase I · an experimental structure of the same protein · chain A against N, TM-score 0.25
- 7OBB · Cryo-EM structure of human RNA polymerase I open complex · an experimental structure of the same protein · chain A against M, TM-score 0.24
- 7OBA · Cryo-EM structure of human RNA polymerase I in complex with RRN3 · an experimental structure of the same protein · chain A against M, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GZS1
- Elsewhere: UniProt Q9GZS1 · AlphaFold DB Q9GZS1
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