UniProt Q9GZS1
DNA-directed RNA polymerase I subunit RPA49 (Q9GZS1)
DNA-directed RNA polymerase I subunit RPA49 (UniProt Q9GZS1): 11 experimental structures and 1 predicted model on GenesisL1, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9GZS1
- Protein
- DNA-directed RNA polymerase I subunit RPA49
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 19 · 7 records with a druggable one
Structures
12 records of Q9GZS1 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7OB9 | Cryo-EM structure of human RNA Polymerase I in elongation state | electron microscopy | M | — | 6 (best 0.83) |
| 7OB9 | Cryo-EM structure of human RNA polymerase I in elongation state | electron microscopy | M | — | — |
| 7OBA | Cryo-EM structure of human RNA Polymerase I in complex with RRN3 | electron microscopy | M | — | 1 (best 0.76) |
| 7OBA | Cryo-EM structure of human RNA polymerase I in complex with RRN3 | electron microscopy | M | — | — |
| 7OBB | Cryo-EM structure of human RNA Polymerase I Open Complex | electron microscopy | M | — | 2 (best 0.76) |
| 7OBB | Cryo-EM structure of human RNA polymerase I open complex | electron microscopy | M | — | — |
| 7VBA | Structure of the pre state human RNA Polymerase I Elongation Complex | electron microscopy | M | — | — |
| 7VBB | Structure of the post state human RNA Polymerase I Elongation Complex | electron microscopy | M | — | 2 (best 0.76) |
| 7VBC | Back track state of human RNA Polymerase I Elongation Complex | electron microscopy | M | — | 2 (best 0.70) |
| 8A43 | Human RNA polymerase I | electron microscopy | N | — | 2 (best 0.78) |
| 8A43 | Human RNA polymerase I | electron microscopy | N | — | — |
| Q9GZS1 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q9GZS1) | predicted | A | — | 4 (best 0.56) |
Experiment against prediction
- 8A43 chain N against the predicted model Q9GZS1: TM-score 0.94, RMSD 0.99 Å
- 8A43 chain N against the predicted model Q9GZS1: TM-score 0.94, RMSD 0.99 Å
- 7VBA chain M against the predicted model Q9GZS1: TM-score 0.92, RMSD 1.61 Å
- 7VBB chain M against the predicted model Q9GZS1: TM-score 0.91, RMSD 1.61 Å
- 7VBC chain M against the predicted model Q9GZS1: TM-score 0.91, RMSD 1.61 Å
- 7OBB chain M against the predicted model Q9GZS1: TM-score 0.90, RMSD 1.58 Å
- 7OBB chain M against the predicted model Q9GZS1: TM-score 0.90, RMSD 1.58 Å
- 7OBA chain M against the predicted model Q9GZS1: TM-score 0.89, RMSD 1.60 Å
- 7OBA chain M against the predicted model Q9GZS1: TM-score 0.89, RMSD 1.60 Å
- 7OB9 chain M against the predicted model Q9GZS1: TM-score 0.45, RMSD 3.18 Å
Elsewhere
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