UniProt Q9NVU0
DNA-directed RNA polymerase III subunit RPC5 (Q9NVU0)
DNA-directed RNA polymerase III subunit RPC5 (UniProt Q9NVU0): 29 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9NVU0
- Protein
- DNA-directed RNA polymerase III subunit RPC5
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 45 · 15 records with a druggable one
Structures
30 records of Q9NVU0 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7A6H | Cryo-EM structure of human apo RNA Polymerase III | electron microscopy | M | — | 2 (best 0.76) |
| 7A6H | Cryo-EM structure of human apo RNA polymerase III | electron microscopy | M | — | — |
| 7AE1 | Cryo-EM structure of human RNA Polymerase III elongation complex 1 | electron microscopy | M | — | 4 (best 0.77) |
| 7AE1 | Cryo-EM structure of human RNA polymerase III elongation complex 1 | electron microscopy | M | — | — |
| 7AE3 | Cryo-EM structure of human RNA Polymerase III elongation complex 3 | electron microscopy | M | — | 4 (best 0.78) |
| 7AE3 | Cryo-EM structure of human RNA polymerase III elongation complex 3 | electron microscopy | M | — | — |
| 7AEA | Cryo-EM structure of human RNA Polymerase III elongation complex 2 | electron microscopy | M | — | 2 (best 0.76) |
| 7AEA | Cryo-EM structure of human RNA polymerase III elongation complex 2 | electron microscopy | M | — | — |
| 7AST | Apo Human RNA Polymerase III | electron microscopy | K | — | 1 (best 0.67) |
| 7AST | Apo human RNA polymerase III | electron microscopy | K | — | — |
| 7ASU | Crystal structure of tWHD1 of Rpc5 subunit of human RNA Polymerase III | x-ray diffraction | A | ZN | 2 (best 0.38) |
| 7ASU | Crystal structure of TWHD1 of RPC5 subunit of human RNA polymerase III | x-ray diffraction | A | ZN | — |
| 7ASV | Crystal structure of tWHD2 of Rpc5 subunit of human RNA Polymerase III | x-ray diffraction | B, A | — | 1 (best 0.29) |
| 7ASV | Crystal structure of TWHD2 of RPC5 subunit of human RNA polymerase III | x-ray diffraction | B, A | — | — |
| 7D58 | cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | M | — | 3 (best 0.79) |
| 7D58 | Cryo-EM structure of human RNA polymerase III in elongating state | electron microscopy | M | — | — |
| 7D59 | cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | M | — | 5 (best 0.81) |
| 7D59 | Cryo-EM structure of human RNA polymerase III in apo state | electron microscopy | M | — | — |
| 7DN3 | Structure of Human RNA Polymerase III elongation complex | electron microscopy | M | — | 4 (best 0.75) |
| 7DN3 | Structure of human RNA polymerase III elongation complex | electron microscopy | M | — | — |
| 7DU2 | RNA polymerase III EC complex in post-translocation state | electron microscopy | M | — | 2 (best 0.75) |
| 7DU2 | RNA polymerase III ec complex in post-translocation state | electron microscopy | M | — | — |
| 7FJI | human Pol III elongation complex | electron microscopy | M | — | 1 (best 0.76) |
| 7FJI | Human pol III elongation complex | electron microscopy | M | — | — |
| 7FJJ | human Pol III pre-termination complex | electron microscopy | M | — | 2 (best 0.71) |
| 7FJJ | Human pol III pre-termination complex | electron microscopy | M | — | — |
| 8ITY | human RNA polymerase III pre-initiation complex closed DNA 1 | electron microscopy | M | — | 4 (best 0.82) |
| 8IUE | RNA polymerase III pre-initiation complex melting complex 1 | electron microscopy | M | — | 3 (best 0.80) |
| 8IUH | RNA polymerase III pre-initiation complex open complex 1 | electron microscopy | M | — | 2 (best 0.82) |
| Q9NVU0 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC5 (Q9NVU0) | predicted | A | — | 3 (best 0.64) |
Ligands
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 7ASU chain A against the predicted model Q9NVU0: TM-score 0.97, RMSD 1.01 Å
- 7ASU chain A against the predicted model Q9NVU0: TM-score 0.97, RMSD 1.01 Å
- 7FJJ chain M against the predicted model Q9NVU0: TM-score 0.89, RMSD 2.23 Å
- 7FJJ chain M against the predicted model Q9NVU0: TM-score 0.89, RMSD 2.23 Å
- 7FJI chain M against the predicted model Q9NVU0: TM-score 0.88, RMSD 2.24 Å
- 7FJI chain M against the predicted model Q9NVU0: TM-score 0.88, RMSD 2.24 Å
- 7A6H chain M against the predicted model Q9NVU0: TM-score 0.88, RMSD 2.35 Å
- 7A6H chain M against the predicted model Q9NVU0: TM-score 0.88, RMSD 2.35 Å
- 7D58 chain M against the predicted model Q9NVU0: TM-score 0.82, RMSD 2.64 Å
- 7D58 chain M against the predicted model Q9NVU0: TM-score 0.82, RMSD 2.64 Å
Elsewhere
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