MolNFT v1 · #173220 · protein
Crystal structure of TWHD2 of RPC5 subunit of human RNA polymerase III
7ASV · DNA-directed RNA polymerase III subunit RPC5: “Crystal structure of TWHD2 of RPC5 subunit of human RNA polymerase III”. X-ray diffraction, 1 pocket (best druggability 0.29). MolNFT v1 #173220 on GenesisL1: 3D structure, binding…
- PDB
- 7ASV
- Type
- protein
- Length
- 310 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-directed RNA polymerase III subunit RPC5
- UniProt
- Q9NVU0
- Pockets
- 1 · best druggability 0.29
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | DNA-directed RNA polymerase III subunit RPC5 | protein | 155 | 52% helix, 14% strand | Q9NVU0 |
Ligands and binding sites
- ACT · Acetate ion · additive · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.29 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- B–A · 1601 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered, artifact).
Compared structures
- 7ASV · Crystal structure of tWHD2 of Rpc5 subunit of human RNA Polymerase III · the same entry in another collection · chain B against B, TM-score 1.00
- Q9NVU0 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC5… · a predicted model of the same protein · chain B against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NVU0
- Elsewhere: RCSB PDB 7ASV · PDBe 7ASV · UniProt Q9NVU0
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