Research workbench
Crystal structure of TWHD2 of RPC5 subunit of human RNA polymerase III
Analyse Crystal structure of TWHD2 of RPC5 subunit of human RNA polymerase III in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ASV
- Type
- protein
- Length
- 310 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-directed RNA polymerase III subunit RPC5
- UniProt
- Q9NVU0
- Pockets
- 1 · best druggability 0.29
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | DNA-directed RNA polymerase III subunit RPC5 | protein | 155 | 52% helix, 14% strand | Q9NVU0 |
Ligands and binding sites
- ACT · Acetate ion · additive · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.29 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- B–A · 1601 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered, artifact).
Compared structures
- 7ASV · Crystal structure of tWHD2 of Rpc5 subunit of human RNA Polymerase III · the same entry in another collection · chain B against B, TM-score 1.00
- Q9NVU0 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC5… · a predicted model of the same protein · chain B against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NVU0
- Elsewhere: RCSB PDB 7ASV · PDBe 7ASV · UniProt Q9NVU0
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